Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
| ▸ | BAD | Q92934 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3169205 | 0.76 | HDAC4 (0.52) | HDAC4HDAC2HDAC8BCL2L1BAD | |
| SCHEMBL7531576 | 0.74 | HDAC4 (0.50) | HDAC4HDAC2HDAC8 | |
| SCHEMBL6004412 | 0.74 | HDAC4 (0.50) | HDAC4HDAC2HDAC8 | |
| SCHEMBL4961033 | 0.73 | CHRNB2 (0.55) | DRD2HDAC4HDAC2HDAC8 | |
| SCHEMBL12290553 | 0.72 | TSHR (0.45) | HDAC4HDAC2HDAC8 | |
| SCHEMBL31614201 | 0.72 | ABCB1 (0.45) | HDAC4HDAC2HDAC8 | |
| SCHEMBL11408083 | 0.71 | HTR1A (0.45) | DRD2 | |
| SCHEMBL2908743 | 0.71 | CHRNB2 (0.37) | DRD2DRD3 | |
| SCHEMBL791622 | 0.70 | PLAU (0.40) | — | |
| SCHEMBL4962052 | 0.69 | CHRNB2 (0.55) | DRD2HDAC4HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017107789-A1 | COMPOUND HAVING CHIRAL SPIROBIINDANE SKELETON AND PREPARATION METHOD THEREFOR | 浙江九洲药业股份有限公司 | 2017-06-29 | — | — | WO | disclosed |