Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 2/20 | 0.53 |
| ▸ | CTSS | P25774 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | MME | P08473 | 1/20 | 0.44 |
| ▸ | ACE | P12821 | 1/20 | 0.44 |
| ▸ | CPA1 | P15085 | 1/20 | 0.44 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.44 |
| ▸ | REN | P00797 | 13/20 | 0.43 |
| ▸ | CTSD | P07339 | 1/20 | 0.42 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.42 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.42 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.42 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.42 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.42 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1905139 | 1.00 | CTSK (0.53) | CTSKCTSSCYP3A4MMEACE | |
| SCHEMBL1905137 | 1.00 | CTSK (0.53) | CTSKCTSSCYP3A4MMEACE | |
| SCHEMBL1908220 | 0.91 | CTSS (0.64) | CTSKCTSSCYP3A4PSMB1PSMB8 | |
| SCHEMBL1432298 | 0.87 | CTSK (0.53) | CTSKCTSSCYP3A4MMEACE | |
| SCHEMBL1432294 | 0.87 | CTSK (0.53) | CTSKCTSSCYP3A4MMEACE | |
| SCHEMBL1432297 | 0.87 | CTSK (0.53) | CTSKCTSSCYP3A4MMEACE | |
| SCHEMBL1905660 | 0.85 | MME (0.51) | CTSKCTSSMMEACECPA1 | |
| SCHEMBL1907287 | 0.81 | MME (0.51) | CTSKCTSSMMEACECPA1 | |
| SCHEMBL1905678 | 0.80 | MME (0.43) | CTSKCTSSMMEACECPA1 | |
| SCHEMBL1432788 | 0.76 | CTSS (0.65) | CTSKCTSSCYP3A4PSMB1PSMB8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011051673-A1 | AMINOTHIAZOLE DERIVATIVES USEFUL AS KLK1 INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | disclosed |