Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 8/20 | 0.64 |
| ▸ | CTSK | P43235 | 7/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.50 |
| ▸ | CTSL | P07711 | 3/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.46 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 2/20 | 0.43 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.43 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.43 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.43 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.43 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1905136 | 0.91 | CTSK (0.53) | CTSSCTSKCYP3A4CTSBPSMB1 | |
| SCHEMBL1905137 | 0.91 | CTSK (0.53) | CTSSCTSKCYP3A4CTSBPSMB1 | |
| SCHEMBL1905139 | 0.91 | CTSK (0.53) | CTSSCTSKCYP3A4CTSBPSMB1 | |
| SCHEMBL1432788 | 0.85 | CTSS (0.65) | CTSSCTSKCYP3A4CTSLSCN9A | |
| SCHEMBL1905678 | 0.84 | MME (0.43) | CTSSCTSKPSMB8PSMB5 | |
| SCHEMBL6441367 | 0.83 | CTSS (0.56) | CTSSCTSKCYP3A4CTSLSCN9A | |
| SCHEMBL6441360 | 0.83 | CTSS (0.56) | CTSSCTSKCYP3A4CTSLSCN9A | |
| SCHEMBL6441362 | 0.83 | CTSS (0.56) | CTSSCTSKCYP3A4CTSLSCN9A | |
| SCHEMBL7860818 | 0.83 | CTSS (0.79) | CTSSCTSKCYP3A4CTSLCTSB | |
| SCHEMBL1905660 | 0.82 | MME (0.51) | CTSSCTSKPSMB8PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011051673-A1 | AMINOTHIAZOLE DERIVATIVES USEFUL AS KLK1 INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | disclosed |