Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | AGXT | P21549 | 2/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22868016 | 0.80 | ATM (0.47) | MAPK1L3MBTL1TSHRATMTDP1 | |
| SCHEMBL12808595 | 0.77 | LMNA (0.38) | MAPK1L3MBTL1RAPGEF4CYP1A2CYP2A6 | |
| SCHEMBL18266512 | 0.77 | LMNA (0.38) | MAPK1L3MBTL1RAPGEF4CYP1A2CYP2A6 | |
| SCHEMBL16010180 | 0.76 | LMNA (0.43) | KDM5ATDP1KMT2AALDH1A1LMNA | |
| SCHEMBL2623502 | 0.74 | MAPT (0.44) | TSHRTDP1KMT2AALDH1A1LMNA | |
| SCHEMBL19908573 | 0.74 | TRPA1 (0.35) | MAPK1L3MBTL1TDP1RAPGEF4CYP1A2 | |
| SCHEMBL14677318 | 0.72 | ACHE (0.41) | KDM5ATDP1KMT2AALDH1A1LMNA | |
| SCHEMBL14678529 | 0.72 | IDO1 (0.48) | KDM5ALMNAIDO1 | |
| SCHEMBL11449778 | 0.72 | CYP1A2 (0.43) | MAPK1L3MBTL1TDP1RAPGEF4CYP1A2 | |
| SCHEMBL14676903 | 0.72 | SLC6A2 (0.37) | TSHRTDP1CYP1A2KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2855475-B1 | ALPHA-CARBOLINES FOR THE TREATMENT OF CANCER | UNIVERSITÀ DEGLI STUDI DI MILANO - BICOCCA (IT) | 2017-06-28 | — | — | EP | disclosed |