Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | MMP3 | P08254 | 1/20 | 0.56 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.56 |
| ▸ | MMP13 | P45452 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1905231 | 1.00 | KMT2A (0.57) | KMT2AMMP3AKR1B1PTPN1MMP13 | |
| SCHEMBL1905235 | 1.00 | KMT2A (0.57) | KMT2AMMP3AKR1B1PTPN1MMP13 | |
| SCHEMBL1902256 | 0.85 | KMT2A (0.57) | KMT2APTPN1 | |
| SCHEMBL1902258 | 0.85 | KMT2A (0.57) | KMT2APTPN1 | |
| SCHEMBL1902254 | 0.85 | KMT2A (0.57) | KMT2APTPN1 | |
| SCHEMBL23578840 | 0.85 | TDP1 (0.54) | KMT2A | |
| SCHEMBL7859584 | 0.85 | TDP1 (0.54) | KMT2A | |
| SCHEMBL10492272 | 0.81 | AKR1B1 (0.78) | KMT2AMMP3AKR1B1PTPN1MMP13 | |
| SCHEMBL10492265 | 0.81 | AKR1B1 (0.78) | KMT2AMMP3AKR1B1PTPN1MMP13 | |
| SCHEMBL10492318 | 0.81 | POLB (0.66) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7947717-B2 | Inhibitors of lethal factor protease | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2011-05-24 | — | — | US | disclosed |
| US-20100016292-A1 | INHIBITORS OF LETHAL FACTOR PROTEASE | THE BURNHAM INSTITUTE (US) | 2010-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100016292-A1 | INHIBITORS OF LETHAL FACTOR PROTEASE | APAF1, F11, SERPINB1 | KMT2A 3345/4885MMP3 74/4885AKR1B1 2715/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.