Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29483829 | 0.80 | SMN1; SMN2 (0.56) | SMN1; SMN2MAPTPOLBMEN1KMT2A | |
| SCHEMBL17509 | 0.80 | SMN1; SMN2 (0.56) | SMN1; SMN2MAPTPOLBMEN1KMT2A | |
| SCHEMBL29977958 | 0.78 | SMN1; SMN2 (0.59) | SMN1; SMN2MAPTPOLBMEN1KMT2A | |
| SCHEMBL4804914 | 0.78 | SMN1; SMN2 (0.59) | SMN1; SMN2MAPTPOLBMEN1KMT2A | |
| SCHEMBL1256644 | 0.78 | SMN1; SMN2 (0.59) | SMN1; SMN2MAPTPOLBMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL4803286 | 0.78 | SMN1; SMN2 (0.55) | SMN1; SMN2MAPTPOLBMEN1KMT2A | |
| SCHEMBL188710 | 0.78 | ALDH1A1 (0.63) | SMN1; SMN2MAPTPOLBMEN1KMT2A | |
| SCHEMBL4804922 | 0.78 | KDM4E (0.59) | SMN1; SMN2MAPTPOLBMEN1KMT2A | |
| SCHEMBL2633979 | 0.78 | KDM4E (0.59) | SMN1; SMN2MAPTPOLBMEN1KMT2A | |
| SCHEMBL23904091 | 0.77 | SMN1; SMN2 (0.53) | SMN1; SMN2MAPTPOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012027261-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | AMGEN INC. (US) | 2012-03-01 | — | — | WO | disclosed |