Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | LIPA | P38571 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3518173 | 0.82 | MEN1 (0.32) | MEN1ALDH1A1LMNAALOX12KMT2A | |
| SCHEMBL3516359 | 0.76 | HMGCR (0.46) | TDP1HSD11B1MEN1ALDH1A1LMNA | |
| SCHEMBL15492445 | 0.76 | ALDH1A1 (0.37) | TDP1HSD11B1MEN1ALDH1A1LMNA | |
| SCHEMBL20899828 | 0.73 | HMGCR (0.32) | MEN1ALDH1A1LMNAALOX12KMT2A | |
| SCHEMBL2151643 | 0.72 | GAA (0.43) | TDP1HSD11B1ALDH1A1LMNAALOX12 | |
| SCHEMBL13194698 | 0.71 | MEN1 (0.31) | MEN1ALDH1A1LMNAALOX12KMT2A | |
| SCHEMBL11117598 | 0.71 | LIPA (0.42) | HSD11B1MEN1ALDH1A1LMNAALOX12 | |
| SCHEMBL7112401 | 0.71 | TSHR (0.39) | MEN1ALDH1A1LMNAALOX12KMT2A | |
| SCHEMBL10147065 | 0.70 | LIPA (0.31) | LIPA | |
| SCHEMBL11029634 | 0.70 | LMNA (0.42) | TDP1HSD11B1ALDH1A1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2693882-B1 | SUBSTITUTED CYCLOPROPYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK SHARP & DOHME (US) | 2017-06-28 | — | — | EP | disclosed |