Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.41 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1905963 | 1.00 | LCK (0.48) | LCKL3MBTL1PTPN1LMNAMAPT | |
| SCHEMBL1901459 | 0.88 | OPRD1 (0.45) | LCKOPRD1MCHR1CTSSCTSK | |
| SCHEMBL1902805 | 0.87 | OPRD1 (0.46) | LCKOPRD1MCHR1CTSSCTSK | |
| SCHEMBL1902802 | 0.87 | OPRD1 (0.46) | LCKOPRD1MCHR1CTSSCTSK | |
| SCHEMBL1906797 | 0.87 | OPRD1 (0.47) | LCKOPRD1MCHR1CTSSCTSK | |
| SCHEMBL1906792 | 0.87 | OPRD1 (0.47) | LCKOPRD1MCHR1CTSSCTSK | |
| SCHEMBL1901386 | 0.86 | MCHR1 (0.46) | LCKLMNAOPRD1MCHR1CTSS | |
| SCHEMBL1901384 | 0.86 | MCHR1 (0.46) | LCKLMNAOPRD1MCHR1CTSS | |
| SCHEMBL1906667 | 0.86 | MCHR1 (0.44) | LCKMAPTOPRD1MCHR1CTSS | |
| SCHEMBL1906669 | 0.86 | MCHR1 (0.44) | LCKMAPTOPRD1MCHR1CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011051671-A1 | AMINOPYRIDINE DERIVATIVES AS KALLIKREIN INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | claimed |
| WO-2011051671-A1 | AMINOPYRIDINE DERIVATIVES AS KALLIKREIN INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | disclosed |