Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 2/20 | 0.40 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1901459 | 0.89 | OPRD1 (0.45) | SMN1; SMN2OPRD1CTSSCTSKTACR1 | |
| SCHEMBL1905963 | 0.86 | LCK (0.48) | MAPTKMT2AMAPK1OPRD1KDM4E | |
| SCHEMBL1905965 | 0.86 | LCK (0.48) | MAPTKMT2AMAPK1OPRD1KDM4E | |
| SCHEMBL1906797 | 0.86 | OPRD1 (0.47) | OPRD1CTSSCTSKTACR1LCK | |
| SCHEMBL1906792 | 0.86 | OPRD1 (0.47) | OPRD1CTSSCTSKTACR1LCK | |
| SCHEMBL1904790 | 0.84 | OPRD1 (0.48) | OPRD1CTSSCTSKLCKPSMB8 | |
| SCHEMBL1904838 | 0.83 | TACR1 (0.44) | MEN1MAPTKMT2ATP53OPRD1 | |
| SCHEMBL1902805 | 0.82 | OPRD1 (0.46) | OPRD1CTSSCTSKLCKPSMB8 | |
| SCHEMBL1902802 | 0.82 | OPRD1 (0.46) | OPRD1CTSSCTSKLCKPSMB8 | |
| SCHEMBL1905132 | 0.81 | PSMB8 (0.53) | OPRD1CTSSCTSKLCKPSMB8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011051671-A1 | AMINOPYRIDINE DERIVATIVES AS KALLIKREIN INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | claimed |
| WO-2011051671-A1 | AMINOPYRIDINE DERIVATIVES AS KALLIKREIN INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | disclosed |