Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.54 |
| ▸ | DRD1 | P21728 | 2/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.48 |
| ▸ | PNMT | P11086 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD5 | P21918 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8055291 | 0.80 | DRD1 (0.50) | DRD2DRD1HRH3PNMTADRA2A | |
| SCHEMBL7645219 | 0.79 | DRD2 (0.55) | DRD2DRD1HRH3PNMTKCNH2 | |
| SCHEMBL1905997 | 0.78 | DRD2 (0.58) | DRD2DRD1HRH3PNMTHTR2A | |
| SCHEMBL1806713 | 0.78 | DRD2 (0.54) | DRD2DRD1HRH3PNMTKCNH2 | |
| SCHEMBL11474315 | 0.78 | DRD1 (0.82) | DRD2DRD1HRH3PNMTDRD4 | |
| SCHEMBL1905994 | 0.78 | DRD2 (0.54) | DRD2DRD1HRH3PNMTKCNH2 | |
| SCHEMBL175086 | 0.76 | DRD2 (0.64) | DRD2DRD1SETD7DRD4DRD5 | |
| SCHEMBL21393017 | 0.76 | MAOA (0.59) | DRD2DRD1PNMTADRA2AADRA2B | |
| SCHEMBL25814865 | 0.75 | DRD2 (0.51) | DRD2DRD1HRH3PNMTKCNH2 | |
| SCHEMBL11457338 | 0.75 | DRD1 (0.60) | DRD2DRD1HRH3KCNH2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2322162-A1 | 5HT2C receptor modulator compositions and methods of use | Arena Pharmaceuticals, Inc. (US) | 2011-05-18 | — | — | EP | disclosed |