Sugi Predict

Sugi Predict / Compounds / SCHEMBL190639

SCHEMBL190639

SCHEMBL190639

C[Si](Br)(Br)c1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ESR1 P03372 1/20 0.44
▸ ESR2 Q92731 1/20 0.44
▸ MAPT P10636 1/20 0.39
▸ NR1H2 P55055 2/20 0.35
▸ NR1H3 Q13133 2/20 0.35
▸ TSHR P16473 4/20 0.35
▸ ALDH1A1 P00352 3/20 0.35
▸ ACHE P22303 2/20 0.35
▸ LMNA P02545 1/20 0.35
▸ ALOX12 P18054 1/20 0.35
▸ TDP1 Q9NUW8 1/20 0.35
▸ NPC1 O15118 3/20 0.32
▸ RAB9A P51151 3/20 0.32
▸ SMN1; SMN2 Q16637 2/20 0.32
▸ CES2 O00748 1/20 0.31
▸ CES1 P23141 1/20 0.31
▸ TP53 P04637 1/20 0.30
▸ BBOX1 O75936 1/20 0.30
▸ EHMT2 Q96KQ7 1/20 0.30
▸ EHMT1 Q9H9B1 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6047833 0.87 ESR1 (0.37) ESR1ESR2MAPTNR1H2NR1H3
SCHEMBL706216 0.83 ESR1 (0.32) ESR1ESR2HPGD
SCHEMBL704384 0.81 ESR1 (0.44) ESR1ESR2MAPTNR1H2NR1H3
SCHEMBL704609 0.81 ESR1 (0.44) ESR1ESR2MAPTNR1H2NR1H3
SCHEMBL18108340 0.77 ESR1 (0.41) ESR1ESR2MAPTNR1H2NR1H3
SCHEMBL18108302 0.77 ESR1 (0.41) ESR1ESR2MAPTNR1H2NR1H3
SCHEMBL1538771 0.75 ESR1 (0.44) ESR1ESR2MAPTNR1H2NR1H3
SCHEMBL707750 0.75 ESR1 (0.44) ESR1ESR2MAPTNR1H2NR1H3
SCHEMBL63526 0.73 ESR1 (0.70) ESR1ESR2MAPTNR1H2NR1H3
SCHEMBL439492 0.73 ESR1 (0.48) ESR1ESR2MAPTNR1H2NR1H3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 267 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8344238-B2 Self-cleaning protective coatings for use with photovoltaic cells SOLYNDRA LLC (US) 2013-01-01 — — US claimed
US-20110000539-A1 Self-cleaning protective coatings for use with photovoltaic cells SOLYNDRA, INC. (US) 2011-01-06 — — US claimed
US-20100326495-A1 Self-cleaning protective coatings for use with photovoltaic cells SOLYNDRA, INC. (US) 2010-12-30 — — US claimed
WO-2007012026-A1 SELF-CLEANING COATINGS SOLYNDRA, INC. (US) 2007-01-25 — — WO claimed
US-20070017567-A1 Self-cleaning protective coatings for use with photovoltaic cells BARNES, CHRISTOPHER 2007-01-25 — — US claimed
EP-3768733-A1 SILICON-TERMINATED TELECHELIC POLYOLEFIN COMPOSITIONS AND PROCESSES FOR PREPARING THE SAME Dow Global Technologies LLC (US) 2021-01-27 — — EP disclosed
EP-3768732-A1 PROCESS FOR FUNCTIONALIZATION OF ORGANO-ZINC COMPOUNDS WITH HALOSILANES USING BASIC NITROGEN CONTAINING HETEROCYCLES AND SILYL-FUNCTIONALIZED COMPOUNDS PREPARED THEREBY Dow Global Technologies LLC (US) 2021-01-27 — — EP disclosed
US-20210017311-A1 SILICON-TERMINATED TELECHELIC POLYOLEFIN COMPOSITIONS AND PROCESSES FOR PREPARING THE SAME DOW GLOBAL TECHNOLOGIES LLC 2021-01-21 — — US disclosed
US-20210017195-A1 PROCESS FOR FUNCTIONALIZATION OF ORGANO-ZINC COMPOUNDS WITH HALOSILANES USING BASIC NITROGEN CONTAINING HETEROCYCLES AND SILYL-FUNCTIONALIZED COMPOUNDS PREPARED THEREBY DOW GLOBAL TECHNOLOGIES LLC (US) 2021-01-21 — — US disclosed
CN-111868109-A Method for functionalizing organozinc compounds with halosilanes using basic nitrogen-containing heterocycles and silane-functionalized compounds prepared therefrom 陶氏环球技术有限责任公司 2020-10-30 — — CN disclosed
CN-111868110-A Silicon-terminated telechelic polyolefin compositions and methods of making the same 陶氏环球技术有限责任公司 2020-10-30 — — CN disclosed
CN-107624080-B Method for forming cyclic siloxane compounds from organodihalosilanes 美国陶氏有机硅公司 2020-04-21 — — CN disclosed
US-5641849-A Method for producing polysilanes OSAKA GAS COMPANY LIMITED (JP) 1997-06-24 — — US disclosed
EP-0673960-A1 Method for producing polysilanes OSAKA GAS CO., LTD. (JP) 1995-09-27 — — EP disclosed
EP-0460556-B1 Polycarbosilanes and process for their preparation KALI CHEMIE AG (DE) 1995-04-12 — — EP disclosed
EP-0375994-B1 Process for preparing polycarbosilanes; polycarbosilanes obtained by this process KALI CHEMIE AG (DE) 1994-03-16 — — EP disclosed
US-5204434-A Grignard condensation of dichlorosilane with dibromo compound KALI-CHEMIE AG (DE) 1993-04-20 — — US disclosed
US-5087685-A PROCESS FOR PREPARING POLYCARBOSILANES AND NEW POLYCARBOSILANES KALI-CHEMIE AKTIENGESELLSCHAFT (DE) 1992-02-11 — — US disclosed
EP-0460556-A2 Polycarbosilanes and process for their preparation Kali-Chemie Aktiengesellschaft (DE) 1991-12-11 — — EP disclosed
EP-0375994-A1 Process for preparing polycarbosilanes; polycarbosilanes obtained by this process Kali-Chemie Aktiengesellschaft (DE) 1990-07-04 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210017195-A1 PROCESS FOR FUNCTIONALIZATION OF ORGANO-ZINC COMPOUNDS WITH HALOSILANES USING BASIC NITROGEN CONTAINING HETEROCYCLES AND SILYL-FUNCTIONALIZED COMPOUNDS PREPARED THEREBY ZRANB2, NISCH, ZKSCAN2 ESR1 4445/4885ESR2 3906/4885MAPT 4473/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.