Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DUSP3 | P51452 | 9/20 | 1.00 |
| ▸ | DNMT1 | P26358 | 3/20 | 0.83 |
| ▸ | PTPN1 | P18031 | 10/20 | 0.81 |
| ▸ | PTPRC | P08575 | 5/20 | 0.81 |
| ▸ | DUSP1 | P28562 | 5/20 | 0.81 |
| ▸ | PTPN7 | P35236 | 5/20 | 0.81 |
| ▸ | CDC25A | P30304 | 4/20 | 0.81 |
| ▸ | MEN1 | O00255 | 5/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.79 |
| ▸ | POLB | P06746 | 3/20 | 0.79 |
| ▸ | BLM | P54132 | 3/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.62 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | GALK1 | P51570 | 1/20 | 0.62 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | PLEC | Q15149 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1906891 | 1.00 | DUSP3 (1.00) | DUSP3DNMT1PTPN1PTPRCDUSP1 | |
| SCHEMBL1906889 | 1.00 | DUSP3 (1.00) | DUSP3DNMT1PTPN1PTPRCDUSP1 | |
| SCHEMBL4411170 | 0.91 | DUSP3 (1.00) | DUSP3DNMT1PTPN1PTPRCDUSP1 | |
| SCHEMBL4411166 | 0.91 | DUSP3 (1.00) | DUSP3DNMT1PTPN1PTPRCDUSP1 | |
| SCHEMBL4411173 | 0.91 | DUSP3 (1.00) | DUSP3DNMT1PTPN1PTPRCDUSP1 | |
| SCHEMBL8931565 | 0.90 | PTPN1 (1.00) | DUSP3DNMT1PTPN1PTPRCDUSP1 | |
| SCHEMBL1903069 | 0.89 | DUSP3 (1.00) | DUSP3DNMT1PTPN1PTPRCDUSP1 | |
| SCHEMBL1903070 | 0.89 | DUSP3 (1.00) | DUSP3DNMT1PTPN1PTPRCDUSP1 | |
| SCHEMBL1903068 | 0.89 | DUSP3 (1.00) | DUSP3DNMT1PTPN1PTPRCDUSP1 | |
| SCHEMBL7859598 | 0.88 | DUSP3 (0.90) | DUSP3DNMT1PTPN1PTPRCDUSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188080-B2 | VHR protein tyrosine phosphatase inhibitors, compositions and methods of use | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2012-05-29 | — | — | US | disclosed |
| US-7947717-B2 | Inhibitors of lethal factor protease | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2011-05-24 | — | — | US | disclosed |
| US-20100016292-A1 | INHIBITORS OF LETHAL FACTOR PROTEASE | THE BURNHAM INSTITUTE (US) | 2010-01-21 | — | — | US | disclosed |
| US-20090105254-A1 | VHR PROTEIN TYROSINE PHOSPHATASE INHIBITORS, COMPOSITIONS AND METHODS OF USE | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105254-A1 | VHR PROTEIN TYROSINE PHOSPHATASE INHIBITORS, COMPOSITIONS AND METHODS OF USE | PTPRR, PTPRS, PTPRCAP | DUSP3 56/4885DNMT1 3552/4885PTPN1 15/4885 |
| US-20100016292-A1 | INHIBITORS OF LETHAL FACTOR PROTEASE | APAF1, F11, SERPINB1 | DUSP3 2075/4885DNMT1 4881/4885PTPN1 2099/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.