Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 18/20 | 0.63 |
| ▸ | FPR2 | P25090 | 17/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19072096 | 0.90 | SCN9A (0.77) | SCN9AFPR2 | |
| SCHEMBL19956171 | 0.87 | SCN9A (0.77) | SCN9AFPR2 | |
| SCHEMBL14743815 | 0.82 | FPR2 (0.74) | SCN9AFPR2 | |
| SCHEMBL14743818 | 0.82 | FPR2 (0.74) | SCN9AFPR2 | |
| SCHEMBL19072315 | 0.82 | SCN9A (0.66) | SCN9AFPR2 | |
| SCHEMBL6394883 | 0.80 | HPGD (0.63) | CYP1A2CYP2C9CYP2C19KMT2AL3MBTL1 | |
| SCHEMBL2927049 | 0.80 | HPGD (0.67) | CYP1A2CYP2C9CYP2C19KMT2AL3MBTL1 | |
| SCHEMBL14746155 | 0.78 | SCN9A (0.77) | SCN9AFPR2 | |
| SCHEMBL14743534 | 0.78 | SCN9A (1.00) | SCN9AFPR2 | |
| SCHEMBL20117022 | 0.78 | FPR2 (0.80) | SCN9AFPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3293184-B1 | PYRIMIDINE CARBOXAMIDES AS SODIUM CHANNEL BLOCKERS | PURDUE PHARMA LP (US) | 2020-12-16 | — | — | EP | disclosed |
| EP-2964639-B1 | PYRIMIDINE CARBOXAMIDES AS SODIUM CHANNEL BLOCKERS | PURDUE PHARMA LP (US) | 2018-05-02 | — | — | EP | disclosed |
| EP-3293184-A1 | PYRIMIDINE CARBOXAMIDES AS SODIUM CHANNEL BLOCKERS | Purdue Pharma L.P. (US) | 2018-03-14 | — | — | EP | disclosed |
| EP-2753606-B1 | PYRIMIDINES AS SODIUM CHANNEL BLOCKERS | PURDUE PHARMA LP (US) | 2017-07-05 | — | — | EP | disclosed |