Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.67 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 5/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | HTT | P42858 | 4/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6394883 | 0.97 | HPGD (0.63) | HPGDMAPTTSHRHSD17B10LMNA | |
| SCHEMBL981752 | 0.86 | HTT (0.74) | HPGDMAPTTSHRHSD17B10LMNA | |
| SCHEMBL2902905 | 0.86 | HTT (0.54) | HPGDMAPTTSHRHSD17B10LMNA | |
| SCHEMBL6395632 | 0.83 | MAPT (0.57) | HPGDMAPTTSHRHSD17B10LMNA | |
| SCHEMBL13309949 | 0.80 | HPGD (1.00) | HPGDMAPTTSHRHSD17B10LMNA | |
| SCHEMBL19072152 | 0.80 | SCN9A (0.63) | KMT2ACYP1A2CYP2C9CYP2C19L3MBTL1 | |
| SCHEMBL2185490 | 0.79 | KDM4E (0.49) | HPGDMAPTTSHRHSD17B10MAPK1 | |
| SCHEMBL26070211 | 0.79 | LMNA (0.78) | HPGDMAPTTSHRHSD17B10LMNA | |
| SCHEMBL981610 | 0.78 | P2RY12 (0.56) | HPGDMAPTTSHRHSD17B10LMNA | |
| SCHEMBL13111332 | 0.78 | HPGD (0.72) | HPGDMAPTTSHRHSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217606-A1 | SOLUBILIZED THIAZOLOPYRIDINES | Sirtris Pharmaceuticals, Inc. (US) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009061453-A1 | SOLUBILIZED THIAZOLOPYRIDINES | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-05-14 | — | — | WO | disclosed |