Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | CYP19A1 | P11511 | 12/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | TNF | P01375 | 1/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.47 |
| ▸ | IL6 | P05231 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.47 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.47 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | GLUL | P15104 | 1/20 | 0.47 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.47 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14962034 | 1.00 | LMNA (0.67) | LMNAMAPTCYP19A1CYP3A4HSD17B10 | |
| SCHEMBL13259847 | 1.00 | LMNA (0.67) | LMNAMAPTCYP19A1CYP3A4HSD17B10 | |
| SCHEMBL11650163 | 0.93 | LMNA (0.70) | LMNAMAPTCYP19A1CYP3A4HSD17B10 | |
| SCHEMBL17775770 | 0.83 | LMNA (0.77) | LMNAMAPTCYP19A1CYP3A4 | |
| SCHEMBL27046927 | 0.82 | LMNA (0.72) | LMNAMAPTCYP19A1CYP3A4HSD17B10 | |
| SCHEMBL27046925 | 0.82 | LMNA (0.72) | LMNAMAPTCYP19A1CYP3A4HSD17B10 | |
| SCHEMBL17852532 | 0.82 | LMNA (0.65) | LMNAMAPTCYP19A1CYP3A4HSD17B10 | |
| SCHEMBL6703601 | 0.82 | LMNA (0.65) | LMNAMAPTCYP19A1CYP3A4HSD17B10 | |
| SCHEMBL27046922 | 0.82 | LMNA (0.75) | LMNAMAPTCYP19A1CYP3A4HSD17B10 | |
| Methandrostenolone SCHEMBL4435272 | 0.81 | LMNA (1.00) | LMNAMAPTCYP19A1CYP3A4HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3238781-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF FLUID ACCUMULATION IN AND/ OR UNDER THE RETINA | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2017-11-01 | — | — | EP | disclosed |
| EP-2977084-B1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF FLUID ACCUMULATION IN AND/ OR UNDER THE RETINA | INSERM (INSTITUT NAT DE LA SANTÉ ET DE LA RECH MÉDICALE) (FR) | 2017-07-05 | — | — | EP | disclosed |