Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methandrostenolone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 1.00 |
| ▸ | CYP19A1 | P11511 | 9/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | GUSB | P08236 | 1/20 | 0.65 |
| ▸ | SHBG | P04278 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.60 |
| ▸ | PGR | P06401 | 2/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.60 |
| ▸ | HTR2B | P41595 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methandrostenolone SCHEMBL140928 | 1.00 | LMNA (1.00) | LMNAMAPTCYP19A1CYP3A4GUSB | |
| Methandrostenolone SCHEMBL28423591 | 1.00 | LMNA (1.00) | LMNAMAPTCYP19A1CYP3A4GUSB | |
| Methandrostenolone SCHEMBL8408550 | 1.00 | LMNA (1.00) | LMNAMAPTCYP19A1CYP3A4GUSB | |
| Methandrostenolone SCHEMBL21177905 | 1.00 | LMNA (1.00) | LMNAMAPTCYP19A1CYP3A4GUSB | |
| Methandrostenolone SCHEMBL16755284 | 1.00 | LMNA (1.00) | LMNAMAPTCYP19A1CYP3A4GUSB | |
| Methandrostenolone SCHEMBL6395376 | 0.90 | LMNA (0.81) | LMNAMAPTCYP19A1CYP3A4GUSB | |
| SCHEMBL5270893 | 0.90 | LMNA (0.81) | LMNAMAPTCYP19A1CYP3A4ALDH1A1 | |
| SCHEMBL10861103 | 0.90 | LMNA (0.81) | LMNAMAPTCYP19A1CYP3A4ALDH1A1 | |
| SCHEMBL17775770 | 0.87 | LMNA (0.77) | LMNAMAPTCYP19A1CYP3A4 | |
| SCHEMBL27046922 | 0.86 | LMNA (0.75) | LMNAMAPTCYP19A1CYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210199646-A1 | SAMPLE DEPLETION AND ENRICHMENT TO IMPROVE THE QUALITY OF DIAGNOSTIC TEST RESULTS | VERAVAS, INC. | 2021-07-01 | — | — | US | disclosed |
| US-10948484-B2 | Sample depletion and enrichment to improve the quality of diagnostic test results | VERAVAS, INC. (US) | 2021-03-16 | — | — | US | disclosed |
| US-20190137484-A9 | Sample depletion and enrichment to improve the quality of diagnostic test results | VERAVAS, INC. (US) | 2019-05-09 | — | — | US | disclosed |
| US-20180292394-A1 | Sample depletion and enrichment to improve the quality of diagnostic test results | SOLDO JOSHUA CAINE (US) | 2018-10-11 | — | — | US | disclosed |
| US-20150152348-A1 | SYSTEMS AND METHODS FOR COLLECTING, TRANSPORTING AND REPURPOSING OR DESTROYING UNUSED PHARMACEUTICALS | SHARPS COMPLIANCE, INC. OF TEXAS | 2015-06-04 | — | — | US | disclosed |
| EP-2069790-B1 | BINDING SURFACES FOR AFFINITY ASSAYS | BECKMAN COULTER INC (US) | 2015-04-29 | — | — | EP | disclosed |
| US-8518714-B2 | Binding surfaces for affinity assays | BECKMAN COULTER, INC. (US) | 2013-08-27 | — | — | US | disclosed |
| EP-2069790-A2 | BINDING SURFACES FOR AFFINITY ASSAYS | Beckman Coulter, Inc. (US) | 2009-06-17 | — | — | EP | disclosed |
| US-20080207601-A1 | Methods of and Compositions For the Prevention of Anxiety, Substance Abuse, and Dependence | HYTHIAM , INC. (US) | 2008-08-28 | — | — | US | disclosed |
| US-20080176340-A1 | Binding surfaces for affinity assays | BECKMAN COULTER, INC. (US) | 2008-07-24 | — | — | US | disclosed |
| WO-2008057366-A2 | BINDING SURFACES FOR AFFINITY ASSAYS | BECKMAN COULTER, INC. (US) | 2008-05-15 | — | — | WO | disclosed |
| US-20080075772-A1 | PHARMACEUTICAL COMPOSITIONS HAVING NOVEL SCORING PATTERNS AND METHODS OF USING THOSE COMPOSITIONS | ACCU-BREAK TECHNOLOGIES, INC. | 2008-03-27 | — | — | US | disclosed |
| EP-1868593-A2 | IMPROVED METHODS OF AND COMPOSITIONS FOR THE PREVENTION OF ANXIETY, SUBSTANCE ABUSE, AND DEPENDENCE | Hythiam, Inc. (US) | 2007-12-26 | — | — | EP | disclosed |
| US-20070141710-A1 | Stable calibrators for immunoassays | BECKMAN COULTER, INC. (US) | 2007-06-21 | — | — | US | disclosed |
| WO-2006110642-A2 | IMPROVED METHODS OF AND COMPOSITIONS FOR THE PREVENTION OF ANXIETY, SUBSTANCE ABUSE, AND DEPENDENCE | HYTHIAM, INC. (US) | 2006-10-19 | — | — | WO | disclosed |