SCHEMBL19074875

SCHEMBL19074875

O=C(Nc1ccccc1)c1ccc(OCC(F)(F)F)nc1

nearest known ligand 0.66

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.66
EPHX2 P34913 2/20 0.64
CXCR1 P25024 2/20 0.63
CXCR2 P25025 2/20 0.63
POLB P06746 1/20 0.59
MAPK1 P28482 1/20 0.59
SLC6A3 Q01959 1/20 0.59
KCNH2 Q12809 1/20 0.59
TAAR1 Q96RJ0 1/20 0.59
TRPV1 Q8NER1 1/20 0.58
KDM4E B2RXH2 1/20 0.57
NPC1 O15118 1/20 0.57
ALDH1A1 P00352 1/20 0.57
RAB9A P51151 1/20 0.57
CYP2C9 P11712 1/20 0.56
CYP2C19 P33261 1/20 0.56
CYP2J2 P51589 1/20 0.56
DGAT1 O75907 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22212813 0.87 SLC6A3 (0.59) L3MBTL1CXCR1CXCR2SLC6A3KCNH2
SCHEMBL19074879 0.82 CXCR1 (0.64) CXCR1CXCR2KDM4ENPC1ALDH1A1
SCHEMBL19074738 0.82 BACE1 (0.53) L3MBTL1EPHX2KDM4ENPC1ALDH1A1
SCHEMBL6927893 0.81 CXCR2 (0.68) CXCR1CXCR2KDM4ENPC1ALDH1A1
SCHEMBL13702416 0.81 L3MBTL1 (0.68) L3MBTL1EPHX2POLBMAPK1TRPV1
SCHEMBL458559 0.80 L3MBTL1 (1.00) L3MBTL1EPHX2POLBMAPK1ALDH1A1
SCHEMBL29488316 0.80 L3MBTL1 (1.00) L3MBTL1EPHX2POLBMAPK1ALDH1A1
SCHEMBL4504526 0.79 NPC1 (0.65) CXCR1CXCR2SLC6A3KCNH2TAAR1
SCHEMBL6931023 0.79 CXCR1 (0.60) CXCR1CXCR2TRPV1KDM4ENPC1
SCHEMBL13702303 0.78 L3MBTL1 (0.65) L3MBTL1EPHX2POLBMAPK1KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3757102-A1 5-ETHYL-4-METHYL-PYRAZOLE-3-CARBOXAMIDE DERIVATIVE HAVING ACTIVITY AS AGONIST OF TAAR F. Hoffmann-La Roche AG (CH) 2020-12-30 EP disclosed
WO-2017157873-A1 5-ETHYL-4-METHYL-PYRAZOLE-3-CARBOXAMIDE DERIVATIVE HAVING ACTIVITY AS AGONIST OF TAAR F. HOFFMANN-LA ROCHE AG (CH) 2017-09-21 WO disclosed
EP-3187490-A1 SUBSTITUTED BENZAMIDE DERIVATIVES F. Hoffmann-La Roche AG (CH) 2017-07-05 EP disclosed