Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.65 |
| ▸ | RAB9A | P51151 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.55 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.52 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.50 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3817443 | 0.87 | P4HTM (0.63) | P4HTMSLC6A3KCNH2TAAR1TRPV1 | |
| SCHEMBL3784127 | 0.81 | KCNH2 (0.43) | NPC1RAB9AKDM4EALDH1A1P4HTM | |
| SCHEMBL180882 | 0.80 | SLC6A3 (0.54) | P4HTMSLC6A3KCNH2TAAR1TRPV1 | |
| SCHEMBL19074875 | 0.79 | L3MBTL1 (0.66) | NPC1RAB9AKDM4EALDH1A1SLC6A3 | |
| SCHEMBL13210581 | 0.79 | ALDH1A1 (1.00) | NPC1RAB9AKDM4EALDH1A1P4HTM | |
| SCHEMBL30834320 | 0.79 | ALDH1A1 (1.00) | NPC1RAB9AKDM4EALDH1A1P4HTM | |
| SCHEMBL30516118 | 0.79 | HDAC6 (0.56) | SLC6A3KCNH2TAAR1TRPV1HDAC2 | |
| SCHEMBL29045114 | 0.79 | HDAC6 (0.56) | SLC6A3KCNH2TAAR1TRPV1HDAC2 | |
| SCHEMBL23309569 | 0.78 | LMNA (0.74) | NPC1RAB9AALDH1A1LMNA | |
| SCHEMBL2224785 | 0.78 | P2RX7 (0.49) | KDM4EALDH1A1LMNASLC6A3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3757102-A1 | 5-ETHYL-4-METHYL-PYRAZOLE-3-CARBOXAMIDE DERIVATIVE HAVING ACTIVITY AS AGONIST OF TAAR | F. Hoffmann-La Roche AG (CH) | 2020-12-30 | — | — | EP | disclosed |
| EP-3430010-B1 | 5-ETHYL-4-METHYL-PYRAZOLE-3-CARBOXAMIDE DERIVATIVE HAVING ACTIVITY AS AGONIST OF TAAR | HOFFMANN LA ROCHE (CH) | 2020-07-15 | — | — | EP | disclosed |
| WO-2017157873-A1 | 5-ETHYL-4-METHYL-PYRAZOLE-3-CARBOXAMIDE DERIVATIVE HAVING ACTIVITY AS AGONIST OF TAAR | F. HOFFMANN-LA ROCHE AG (CH) | 2017-09-21 | — | — | WO | disclosed |
| US-7589089-B2 | Inhibitors for GlyT-1 | HOFFMANN-LA ROCHE INC. (US) | 2009-09-15 | — | — | US | disclosed |
| US-20080058331-A1 | Inhibitors for GlyT-1 | HOFFMANN-LA ROCHE INC. | 2008-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080058331-A1 | Inhibitors for GlyT-1 | GLRA1, SLC1A2, AGXT | NPC1 448/4885RAB9A 3773/4885KDM4E 1690/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.