Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 4/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.31 |
| ▸ | CDK2 | P24941 | 2/20 | 0.31 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.31 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.31 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.31 |
| ▸ | PYGL | P06737 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1907701 | 0.85 | SMN1; SMN2 (0.36) | ALPLSMN1; SMN2HDAC3HDAC4HDAC1 | |
| SCHEMBL13387526 | 0.85 | MAPT (0.35) | MMEALPLCCNA2CDK2CCNA1 | |
| SCHEMBL13387504 | 0.80 | GPR84 (0.37) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL13387617 | 0.76 | MAPK1 (0.36) | SMN1; SMN2CCNA2CDK2CCNA1 | |
| SCHEMBL13387759 | 0.76 | NQO2 (0.37) | ALPLHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1906671 | 0.75 | HDAC3 (0.38) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| Trifluoroacetic Acid SCHEMBL1907045 | 0.73 | SSTR3 (0.34) | MME | |
| SCHEMBL13387620 | 0.73 | SMN1; SMN2 (0.44) | ALPLSMN1; SMN2HCAR3CCNA2CDK2 | |
| SCHEMBL19101944 | 0.69 | DYRK1A (0.38) | CCNA2CDK2CCNA1 | |
| SCHEMBL15095587 | 0.69 | CHRNA1 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493859-A1 | NEW COMPOUNDS FOR THE TREATMENT OF DISEASES RELATED TO PROTEIN MISFOLDING | Universität Duisburg-Essen (DE) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011050864-A1 | NEW COMPOUNDS FOR THE TREATMENT OF DISEASES RELATED TO PROTEIN MISFOLDING | Universität Duisburg-Essen (DE) | 2011-05-05 | — | — | WO | disclosed |