Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 11/20 | 0.36 |
| ▸ | CDK2 | P24941 | 11/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 11/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.34 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.34 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.34 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.34 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.34 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.34 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13387620 | 0.84 | SMN1; SMN2 (0.44) | DYRK1AMEN1KMT2ACCNA2CDK2 | |
| SCHEMBL13256448 | 0.82 | CCNA2 (0.53) | DYRK1AMEN1KMT2ACCNA2CDK2 | |
| SCHEMBL13387759 | 0.78 | NQO2 (0.37) | DYRK1AMEN1KMT2AMAPT | |
| SCHEMBL1520368 | 0.76 | ALOX15 (0.56) | MEN1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL1906671 | 0.75 | HDAC3 (0.38) | — | |
| SCHEMBL1908029 | 0.75 | ALDH1A1 (0.38) | MAPT | |
| SCHEMBL13388282 | 0.72 | MAPK1 (0.41) | CCNA2CDK2CCNA1 | |
| SCHEMBL4293791 | 0.70 | NPC1 (0.51) | MEN1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL627520 | 0.69 | MAPK1 (0.57) | NPC1RAB9AMAPT | |
| SCHEMBL4290678 | 0.69 | PLA2G7 (0.46) | MEN1KMT2ANPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9701660-B2 | 2,6-diaminopyridine compounds suitable for treating diseases associated with amyloid or amyloid-like proteins or for treating or preventing ocular diseases or conditions associated with a pathological abnormality/change in the tissue of the visual system | AC IMMUNE S.A. (CH) | 2017-07-11 | — | — | US | disclosed |