Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 14/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 5/20 | 0.45 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.41 |
| ▸ | BRD2 | P25440 | 6/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31677882 | 0.81 | PTGDR2 (0.43) | PTGDR2MAP4K4 | |
| SCHEMBL24398370 | 0.81 | BRD4 (0.47) | BRD4BRD2BRD3 | |
| SCHEMBL1906132 | 0.81 | BRD4 (0.48) | BRD4ATAD2BRD2FFAR1BRD3 | |
| SCHEMBL1907803 | 0.81 | BRD4 (0.48) | BRD4ATAD2BRD2FFAR1BRD3 | |
| SCHEMBL16619524 | 0.81 | ATAD2 (0.46) | BRD4ATAD2BRD2PTGDR2FFAR1 | |
| SCHEMBL24398702 | 0.80 | MEN1 (0.46) | BRD4CREBBPPTGDR2 | |
| SCHEMBL29619095 | 0.80 | MEN1 (0.46) | BRD4CREBBPPTGDR2 | |
| SCHEMBL17467705 | 0.80 | MAP4K4 (0.40) | BRD4CREBBPATAD2BRD2MAP4K4 | |
| SCHEMBL29619004 | 0.79 | BRD4 (0.49) | BRD4CREBBPBRD2BRD3 | |
| SCHEMBL29619091 | 0.76 | GABRA5 (0.46) | BRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4236942-A1 | ISOXAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2023-09-06 | — | — | EP | disclosed |
| WO-2022093850-A1 | ISOXAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2022-05-05 | — | — | WO | disclosed |