Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.41 |
| ▸ | LIPC | P11150 | 2/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 2/20 | 0.37 |
| ▸ | BCR | P11274 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18541435 | 0.92 | PAK4 (0.48) | PAK4NAMPTPAK1LIPCABL1 | |
| SCHEMBL17844696 | 0.85 | LIPC (0.40) | PAK4NAMPTPAK1LIPCMAPT | |
| SCHEMBL19753621 | 0.84 | PAK4 (0.47) | PAK4NAMPTPAK1LIPCMEN1 | |
| SCHEMBL18325906 | 0.81 | PAK4 (0.55) | PAK4NAMPTPAK1LIPCGABRD | |
| SCHEMBL19742290 | 0.81 | PAK4 (0.49) | PAK4NAMPTPAK1LIPCMEN1 | |
| SCHEMBL19078937 | 0.79 | NAMPT (0.45) | PAK4NAMPTPAK1 | |
| SCHEMBL19753619 | 0.77 | P2RY12 (0.40) | PAK4NAMPTPAK1LIPCKMT2A | |
| SCHEMBL18325911 | 0.77 | PAK4 (0.54) | PAK4NAMPTPAK1GABRDGABRA1 | |
| SCHEMBL17859366 | 0.77 | PAK4 (0.46) | PAK4NAMPTPAK1LIPCFASN | |
| SCHEMBL19753597 | 0.76 | GABRA5 (0.44) | PAK4LIPCGABRA5MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017117447-A1 | MULTICYCLIC COMPOUNDS AND USES THEREOF | Karyopharm Therapeutics Inc. (US) | 2017-07-06 | — | — | WO | disclosed |