Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.61 |
| ▸ | ACHE | P22303 | 2/20 | 0.57 |
| ▸ | HTR7 | P34969 | 2/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.52 |
| ▸ | DRD4 | P21917 | 3/20 | 0.52 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.51 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4513933 | 0.86 | HRH3 (0.67) | HRH3ACHEHTR7SIGMAR1ALDH1A1 | |
| SCHEMBL4033714 | 0.85 | SIGMAR1 (0.51) | HRH3SIGMAR1DRD4TMEM97CXCR3 | |
| SCHEMBL19075520 | 0.84 | SIGMAR1 (0.49) | SIGMAR1DRD4TMEM97CXCR3ALDH1A1 | |
| SCHEMBL6306548 | 0.81 | ALDH1A1 (0.72) | HRH3SIGMAR1ALDH1A1SMN1; SMN2POLB | |
| SCHEMBL5411899 | 0.80 | HRH3 (0.73) | HRH3ACHE | |
| SCHEMBL26117280 | 0.80 | POLB (0.51) | HRH3SIGMAR1DRD4TMEM97CXCR3 | |
| Hydrochloric Acid SCHEMBL16825107 | 0.80 | ALDH1A1 (0.70) | HRH3SIGMAR1ALDH1A1SMN1; SMN2POLB | |
| SCHEMBL23179563 | 0.79 | HTR7 (0.66) | HRH3ACHEHTR7SIGMAR1DRD4 | |
| SCHEMBL13727882 | 0.79 | HRH3 (0.50) | HRH3ACHEHTR7DRD4ALDH1A1 | |
| SCHEMBL16480142 | 0.79 | HRH3 (0.54) | HRH3ACHEHTR7DRD4CXCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3166939-B1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH INC (US) | 2019-06-05 | — | — | EP | disclosed |
| US-20170190662-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2017-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170190662-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | RDX, C1R, MTX1 | HRH3 1260/4885ACHE 1652/4885HTR7 1969/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.