SCHEMBL1908486

SCHEMBL1908486

CC(C)c1ccccc1C(=O)CC(=O)c1ccccc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 8/20 0.61
MEN1 O00255 6/20 0.61
HPGD P15428 5/20 0.61
MAPT P10636 4/20 0.61
SMN1; SMN2 Q16637 4/20 0.61
CYP3A4 P08684 2/20 0.61
KDM4E B2RXH2 2/20 0.61
ALOX15 P16050 2/20 0.61
MAPK1 P28482 2/20 0.61
CES1 P23141 1/20 0.61
TDP1 Q9NUW8 1/20 0.61
NPC1 O15118 7/20 0.58
RAB9A P51151 3/20 0.55
LMNA P02545 4/20 0.51
ALDH1A1 P00352 2/20 0.50
PLOD2 O00469 2/20 0.50
PLOD3 O60568 1/20 0.50
CYP1A2 P05177 1/20 0.50
CYP2D6 P10635 1/20 0.50
CYP2C9 P11712 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27646876 0.89 KMT2A (0.52) KMT2AMEN1HPGDMAPTSMN1; SMN2
SCHEMBL11289405 0.82 KMT2A (0.81) KMT2AMEN1HPGDMAPTSMN1; SMN2
SCHEMBL11768785 0.81 KMT2A (0.55) KMT2AMEN1HPGDMAPTSMN1; SMN2
Dibenzoylmethane SCHEMBL11176186 0.79 KMT2A (0.74) KMT2AMEN1HPGDMAPTSMN1; SMN2
SCHEMBL9316324 0.78 KMT2A (0.69) KMT2AMEN1HPGDMAPTSMN1; SMN2
Dibenzoylmethane SCHEMBL39582 0.78 MEN1 (1.00) KMT2AMEN1HPGDMAPTSMN1; SMN2
Dibenzoylmethane SCHEMBL10356288 0.78 MEN1 (1.00) KMT2AMEN1HPGDMAPTSMN1; SMN2
Dibenzoylmethane SCHEMBL1704711 0.78 MEN1 (1.00) KMT2AMEN1HPGDMAPTSMN1; SMN2
SCHEMBL38900 0.78 KMT2A (0.65) KMT2AMEN1HPGDMAPTSMN1; SMN2
Dibenzoylmethane SCHEMBL5680105 0.78 KMT2A (0.65) KMT2AMEN1HPGDMAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6355264-B1 WATER RESISTANT/WATERPROOF PROPERTIES AVON PRODUCTS, INC. 2002-03-12 US claimed
US-8912165-B2 Methods of skin treatment and use of water-soluble β-(1,3) glucans as active agents for producing therapeutic skin treatment agents BIOTEC PHARMACON ASA (NO) 2014-12-16 US disclosed
US-20130296265-A1 Methods of Skin Treatment and Use of Water-Soluble Beta-(1,3) Glucans as Active Agents for Producing Therapeutic Skin Treatment Agents BIOTEC PHARMACON ASA (NO) 2013-11-07 US disclosed
US-8501710-B2 Antiulcer agents; wound healing agents BIOTEC PHARMACON ASA (NO) 2013-08-06 US disclosed
WO-2011051712-A1 SECURITY DOCUMENT THE GOVERNOR & COMPANY OF THE BANK OF ENGLAND (GB) 2011-05-05 WO disclosed
US-20080220031-A1 Dermocosmetic Preparations BASF AKTIENGESELLSCHAFT (DE) 2008-09-11 US disclosed
WO-2007123699-A1 METHODS AND COMPOSITIONS FOR MODULATING MELANOGENESIS BY USING A MCLR AGONIST DANA-FARBER CANCER INSTITUTE, INC. (US) 2007-11-01 WO disclosed
US-20070104676-A1 Cosmetic and/or dermatological preparations containing an extract from the seeds of plants of the genus adenanthera COGNIS FRANCE S.A. (FR) 2007-05-10 US disclosed
US-20060194760-A1 Cosmetic preparations BIOTEC ASA (NO) 2006-08-31 US disclosed
US-6964775-B1 Decorative cosmetic preparations BIOTEC ASA (NO) 2005-11-15 US disclosed
US-6858214-B1 Use of nanoscalar water-soluble β-(1,3) glucans BIOTEC ASA (NO) 2005-02-22 US disclosed
US-20050009781-A1 Methods of skin treatment and use of water-soluble beta-(1,3) glucans as active agents for producing therapeutic skin treatment agents BIOTEC PHARMACON ASA (NO) 2005-01-13 US disclosed
US-6706696-B1 MIXTURES OF SPECIFIC GLUCANS AND NUCLEIC ACIDS BIOTEC ASA (NO) 2004-03-16 US disclosed
US-20030180278-A1 Use of a combination of active substances containing bioquinones for the production of cosmetic or dermatological preparations GS DEVELOPMENT A.B. (SE) 2003-09-25 US disclosed
US-6500410-B1 IMPROVING THE PHOTO SENSITIVITY AND SOLUBILITY OF UV LIGHT PROTECTION FACTOR IN SUN PROTECTING AGENTS COMPRISING INCLUDING WATER SOLUBLE BETA-(1,3) GLUCANS WHICH ARE SUBSTANTIALLY FREE FROM BETA-(1,6) LINKAGES BIOTEC PHARMACON ASA (NO) 2002-12-31 US disclosed
US-6497863-B1 PREPARATION COMPRISING WATER SOLUBLE BETA-(1,3) GLUCANS, WHICH ARE SUBSTANTIALLY FREE FROM BETA-(1,6) LINKAGES, ALUMINUM CHLOROHYDRATE, ESTERASE INHIBITORS, AND/OR BACTERICIDAL, RESPECTIVELY BACTERIOSTATIC, AGENTS BIOTEC PHARMACON ASA (NO) 2002-12-24 US disclosed
US-6497865-B1 PREPARATIONS CONTAINING WATER SOLUBLE BETA-(1,3) GLUCANS, SUBSTANTIALLY FREE FROM BETA-(1,6) LINKAGES, AND POLYMERS; DECREASES TENDENCY TO FORMING OF STRESS CRACKS BIOTEC PHARMACON ASA (NO) 2002-12-24 US disclosed
US-6448304-B1 POLYURETHANE, POLYTHIOURETHANE OR DIETHYLENE GLYCOL BISALLYLCARBONATE POLYMER; DIPPING IN SOLUTION CONTAINING A DIBENZOYLMETHANE OR A BENZOTRIZOLE COMPOUND; PLASTIC LENS FOR SPECTACLES WHICH ABSORBS ULTRAVIOLET RAYS; LOW YELLOWNESS HOYA CORPORATION (JP) 2002-09-10 US disclosed
US-6355264-B1 WATER RESISTANT/WATERPROOF PROPERTIES AVON PRODUCTS, INC. 2002-03-12 US disclosed
WO-2001074302-A1 PROLIPOSOMAL ENCAPSULATED PREPARATIONS COGNIS IBERIA, S.L. (ES) 2001-10-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030180278-A1 Use of a combination of active substances containing bioquinones for the production of cosmetic or dermatological preparations SDHA, SDHB, SLC25A20 KMT2A 1702/4885MEN1 1456/4885HPGD 223/4885
US-20080220031-A1 Dermocosmetic Preparations C3AR1, C1S, C1R KMT2A 3446/4885MEN1 247/4885HPGD 827/4885
US-20060194760-A1 Cosmetic preparations GLA, CHIT1, ALG1 KMT2A 3827/4885MEN1 92/4885HPGD 1991/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.