SCHEMBL19085143

SCHEMBL19085143

CNC(=O)Nc1ccc(C2CCCC2)cc1

nearest known ligand 0.59

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.59
HDAC8 Q9BY41 3/20 0.55
HDAC6 Q9UBN7 3/20 0.55
HDAC3 O15379 2/20 0.55
HDAC11 Q96DB2 2/20 0.55
DEGS1 O15121 1/20 0.55
ALDH1A1 P00352 5/20 0.53
MITF O75030 1/20 0.51
KLF5 Q13887 1/20 0.51
HPGD P15428 2/20 0.50
SLC18A3 Q16572 1/20 0.50
JAK3 P52333 1/20 0.50
HDAC1 Q13547 1/20 0.49
RORC P51449 1/20 0.48
NPC1 O15118 2/20 0.48
USP2 O75604 1/20 0.48
RAB9A P51151 1/20 0.47
EPHX1 P07099 1/20 0.47
KMT2A Q03164 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11356835 0.87 HDAC8 (0.64) HDAC8HDAC6HDAC3HDAC11DEGS1
SCHEMBL2047490 0.83 JAK3 (0.74) JAK3
SCHEMBL15157030 0.82 SLC18A3 (0.68) HDAC8HDAC6HDAC3HDAC11DEGS1
SCHEMBL23453344 0.82 HDAC3 (0.55) POLBHDAC8HDAC6HDAC3HDAC11
SCHEMBL23453355 0.81 RAB9A (0.55) HDAC8HDAC6HDAC3HDAC11DEGS1
SCHEMBL3822159 0.81 SLC18A3 (0.67) HDAC8HDAC6HDAC3HDAC11DEGS1
SCHEMBL23406295 0.80 EPHX1 (0.67) ALDH1A1NPC1RAB9AEPHX1KMT2A
SCHEMBL20589977 0.80 EPHX1 (0.71) ALDH1A1NPC1RAB9AEPHX1KMT2A
SCHEMBL26154049 0.80 EPHX1 (0.71) ALDH1A1NPC1RAB9AEPHX1KMT2A
SCHEMBL23406299 0.79 EPHX1 (0.69) ALDH1A1NPC1RAB9AEPHX1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4253536-A2 DIFFUSION RESISTANCE LAYER FOR ANALYTE SENSORS DexCom, Inc. (US) 2023-10-04 EP disclosed
EP-3397163-B1 DIFFUSION RESISTANCE LAYER FOR ANALYTE SENSORS DEXCOM INC (US) 2023-09-13 EP disclosed
EP-3397162-B1 MEMBRANE LAYERS FOR ANALYTE SENSORS DEXCOM INC (US) 2023-09-06 EP disclosed
WO-2017117565-A1 MEMBRANE LAYERS FOR ANALYTE SENSORS DEXCOM, INC. (US) 2017-07-06 WO disclosed
WO-2017117469-A1 DIFFUSION RESISTANCE LAYER FOR ANALYTE SENSORS DEXCOM, INC. (US) 2017-07-06 WO disclosed