Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 5/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12745368 | 0.83 | NR1I2 (0.42) | CFTRNR1I2PTGER4HDAC10HDAC6 | |
| SCHEMBL12827378 | 0.81 | CFTR (0.42) | CFTRNR1I2PTGER4HDAC10HDAC6 | |
| SCHEMBL20808191 | 0.69 | NR1I2 (0.34) | CFTRNR1I2 | |
| SCHEMBL13365257 | 0.69 | CFTR (0.51) | CFTRNR1I2HDAC10HDAC6 | |
| SCHEMBL12745363 | 0.67 | NR1I2 (0.43) | CFTRNR1I2HDAC10HDAC6 | |
| SCHEMBL24944394 | 0.63 | CASR (0.46) | — | |
| SCHEMBL409631 | 0.61 | DNM1 (0.65) | — | |
| SCHEMBL14845739 | 0.59 | CFTR (0.38) | CFTRNR1I2HDAC10HDAC6 | |
| SCHEMBL12745370 | 0.59 | NR1I2 (0.45) | CFTRNR1I2HDAC10HDAC6 | |
| SCHEMBL19085811 | 0.58 | DGAT1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9974781-B2 | Modulators of ATP-binding cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2018-05-22 | — | — | US | disclosed |
| US-20170189389-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2017-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170189389-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | CFTR, ABCB1, ABCC2 | CFTR 1/4885NR1I2 491/4885PTGER4 2380/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.