SCHEMBL19086232 — predicted protein targets

Predicted protein targets (top 9)

	gene	UniProt	supporting neighbours	confidence
▸	EPHX2	P34913	5/20	0.43

▸	PRMT5	O14744	5/20	0.37

▸	WDR77	Q9BQA1	5/20	0.37

▸	MMP13	P45452	1/20	0.37

▸	HCRTR2	O43614	5/20	0.36

▸	TRPA1	O75762	1/20	0.35

▸	SLC8A1	P32418	1/20	0.34

▸	HCRTR1	O43613	3/20	0.34

▸	KLKB1	P03952	1/20	0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL19086207	0.91	PRMT5 (0.36)	PRMT5WDR77HCRTR2HCRTR1
SCHEMBL19086016	0.88	PRMT5 (0.42)	PRMT5WDR77MMP13HCRTR2HCRTR1
SCHEMBL19086238	0.87	EPHX2 (0.42)	EPHX2PRMT5WDR77MMP13TRPA1
SCHEMBL19086007	0.87	PRMT5 (0.40)	PRMT5WDR77HCRTR2
SCHEMBL19086009	0.87	KMT2A (0.42)	PRMT5WDR77HCRTR2HCRTR1
SCHEMBL19086006	0.86	KDM4E (0.38)	PRMT5WDR77
SCHEMBL19086211	0.85	PRMT5 (0.42)	PRMT5WDR77HCRTR2HCRTR1
SCHEMBL19087007	0.84	PRMT5 (0.38)	PRMT5WDR77
SCHEMBL19086981	0.84	PRMT5 (0.38)	PRMT5WDR77
SCHEMBL19086234	0.84	EPHX2 (0.43)	EPHX2PRMT5WDR77MMP13HCRTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2017114275-A1	COMPOUND FOR INHIBITING ROCK, PREPARATION METHOD AND USE OF SAME	成都先导药物开发有限公司	2017-07-06	—	—	WO	disclosed