Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 4/20 | 0.65 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.64 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.64 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.62 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.62 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.62 |
| ▸ | KCNQ1 | P51787 | 2/20 | 0.62 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | BRAF | P15056 | 1/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | CSF1R | P07333 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19087168 | 0.84 | SCN10A (0.61) | KCNK3KCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL19087072 | 0.84 | BCAT2 (0.63) | KCNK3KCNK9MEN1KMT2ATHRB | |
| SCHEMBL19077869 | 0.83 | GRM5 (0.61) | GRM5KCNK3KCNK9KCNQ3KCNQ2 | |
| SCHEMBL19116772 | 0.83 | GRM5 (0.64) | GRM5KCNK3KCNK9KCNQ3KCNQ2 | |
| SCHEMBL17620462 | 0.82 | KCNK3 (0.91) | KCNK3KCNK9MEN1KMT2ATHRB | |
| SCHEMBL19447235 | 0.81 | THRB (0.52) | GRM5KCNK3KCNK9MEN1KMT2A | |
| SCHEMBL8363018 | 0.81 | SMN1; SMN2 (0.76) | KCNK3KCNK9KCNQ3KCNQ2KCNE1 | |
| SCHEMBL19087022 | 0.80 | GRM5 (0.67) | GRM5MEN1KMT2ABRAFTHRB | |
| SCHEMBL23015732 | 0.80 | TDP1 (0.78) | KCNK3MEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL6927318 | 0.79 | GRM5 (1.00) | GRM5KCNQ3KCNQ2KCNE1KCNQ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3792256-A1 | PYRIDINE AND PYRIDIMINE COMPOUNDS AS PI3K-GAMMA INHIBITORS | Incyte Corporation (US) | 2021-03-17 | — | — | EP | disclosed |
| EP-3400221-B1 | PYRAZOL / IMIDAZOL SUBSTITUTED PYRIDINES AS PI3K-GAMMA INHIBITORS | INCYTE CORP (US) | 2020-08-26 | — | — | EP | disclosed |
| US-20170190689-A1 | PYRIDINE AND PYRIDIMINE COMPOUNDS AS PI3K-GAMMA INHIBITORS | INCYTE CORPORATION | 2017-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170190689-A1 | PYRIDINE AND PYRIDIMINE COMPOUNDS AS PI3K-GAMMA INHIBITORS | PIK3CG, PIK3CD, PIK3CB | GRM5 1218/4885KCNK3 1319/4885KCNK9 1642/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.