Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | LDHA | P00338 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17709407 | 0.84 | REN (0.46) | LMNAHTTNPC1GAAKMT2A | |
| SCHEMBL17709303 | 0.81 | SMPD1 (0.52) | NPC1KMT2AMEN1HPGDMTNR1A | |
| SCHEMBL7845389 | 0.76 | LMNA (0.56) | LMNAHTTNPC1GAAKMT2A | |
| SCHEMBL19272912 | 0.74 | L3MBTL1 (0.46) | LMNAKMT2AMEN1MAPTNFKB1 | |
| SCHEMBL19252776 | 0.74 | REN (0.46) | LMNAHTTNPC1GAAKMT2A | |
| SCHEMBL17721710 | 0.73 | PPARA (0.38) | LMNAHTTKMT2AMEN1MAPT | |
| SCHEMBL17709394 | 0.73 | REN (0.45) | LMNAHTTNPC1GAAKMT2A | |
| SCHEMBL17709308 | 0.73 | SMPD1 (0.48) | KMT2AMTNR1AMTNR1BALDH1A1 | |
| SCHEMBL11050331 | 0.72 | HTT (0.55) | LMNAHTTNPC1GAAKMT2A | |
| SCHEMBL16930243 | 0.71 | REN (0.48) | LMNAHTTNPC1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017114812-A1 | COMBINATION THERAPY OF AN HBSAG INHIBITOR AND AN INTERFERON | F. HOFFMANN-LA ROCHE AG (CH) | 2017-07-06 | — | — | WO | disclosed |