Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | DDX3X | O00571 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | PTPRC | P08575 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20469630 | 0.92 | ADRA2A (0.45) | ALOX5DYRK1AADRA2ADDX3XNPC1 | |
| SCHEMBL20022978 | 0.92 | DYRK1A (0.43) | ALOX5DYRK1AADRA2ADDX3XNPC1 | |
| SCHEMBL22917376 | 0.87 | ADRA2A (0.44) | ALOX5DYRK1AADRA2ADDX3XNPC1 | |
| SCHEMBL18671143 | 0.81 | ESR1 (0.43) | DYRK1ANPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL23871266 | 0.81 | NPC1 (0.56) | DYRK1ANPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL20966294 | 0.76 | RIPK1 (0.47) | DYRK1A | |
| SCHEMBL14860721 | 0.74 | KDM4E (0.52) | ADRA2ADDX3XNPC1RAB9AMAOB | |
| SCHEMBL20017371 | 0.73 | DYRK1A (0.45) | ALOX5DYRK1AADRA2ANPC1RAB9A | |
| SCHEMBL19203362 | 0.73 | PRMT3 (0.46) | ALOX5DYRK1AADRA2ANPC1RAB9A | |
| SCHEMBL19557533 | 0.73 | NPC1 (0.53) | DYRK1ANPC1RAB9ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230141101-A1 | PDE4 INHIBITOR COMPOUND AND MEDICAL USE THEREOF | SUZHOU LONGBOTAI PHARMACEUTICALS CO., LTD. (CN) | 2023-05-11 | — | — | US | disclosed |
| US-20170190735-A1 | DERIVATIVES OF DOLAPROINE-DOLAISOLEUINE PEPTIDES | AGENSYS, INC. (US) | 2017-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230141101-A1 | PDE4 INHIBITOR COMPOUND AND MEDICAL USE THEREOF | PDE4B, PDE4A, PDE12 | ALOX5 1816/4885DYRK1A 813/4885ADRA2A 1145/4885 |
| US-20170190735-A1 | DERIVATIVES OF DOLAPROINE-DOLAISOLEUINE PEPTIDES | DDOST, VIP, THPO | ALOX5 2336/4885DYRK1A 2342/4885ADRA2A 4411/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.