Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 7/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19090209 | 0.84 | APOBEC3G (0.47) | MAPTPOLBHPGDALDH1A1ALOX15 | |
| SCHEMBL19090462 | 0.75 | P2RX3 (0.35) | MAPTALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL19090593 | 0.75 | BRD4 (0.34) | — | |
| SCHEMBL19090328 | 0.75 | MAPT (0.48) | MAPTPOLBHPGDALDH1A1ALOX15 | |
| SCHEMBL19090465 | 0.74 | MEN1 (0.39) | MAPTALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL21389479 | 0.71 | BRD4 (0.58) | MAPTPOLBHPGDRXFP1ALDH1A1 | |
| SCHEMBL19090232 | 0.71 | NPC1 (0.43) | HPGDALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL19090464 | 0.70 | P2RX3 (0.36) | MAPTHPGDALDH1A1KMT2AMEN1 | |
| SCHEMBL19090325 | 0.70 | ALDH1A1 (0.46) | MAPTPOLBHPGDALDH1A1KMT2A | |
| SCHEMBL19090323 | 0.68 | BRD4 (0.47) | MAPTPOLBKMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017114843-A1 | XANTHINE DERIVATIVE INHIBITORS OF BET PROTEINS | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2017-07-06 | — | — | WO | disclosed |