Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MDH2 | P40926 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | TYMP | P19971 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19090468 | 0.76 | MAPK1 (0.39) | MAPTGAAKDM4ETSHRLMNA | |
| SCHEMBL19090547 | 0.75 | SMN1; SMN2 (0.38) | MAPTTP53SMN1; SMN2GAAKMT2A | |
| SCHEMBL19090465 | 0.74 | MEN1 (0.39) | MAPTTP53SMN1; SMN2GAAKMT2A | |
| SCHEMBL19090553 | 0.69 | SMN1; SMN2 (0.37) | MAPTTP53SMN1; SMN2GAAKMT2A | |
| SCHEMBL19090464 | 0.68 | P2RX3 (0.36) | MAPTTP53SMN1; SMN2GAAKMT2A | |
| SCHEMBL19090462 | 0.68 | P2RX3 (0.35) | MAPTTP53SMN1; SMN2GAAKMT2A | |
| SCHEMBL10341790 | 0.65 | KMT2A (0.68) | MAPTTP53SMN1; SMN2GAAKMT2A | |
| SCHEMBL2820962 | 0.65 | PPARG (0.54) | MAPTTP53SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL19090459 | 0.63 | MEN1 (0.49) | MAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL13033718 | 0.58 | MGLL (0.59) | MAPTTP53SMN1; SMN2GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017114843-A1 | XANTHINE DERIVATIVE INHIBITORS OF BET PROTEINS | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2017-07-06 | — | — | WO | disclosed |