Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 6/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 9/20 | 0.40 |
| ▸ | MAOB | P27338 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL191480 | 0.79 | GCK (0.54) | GCKAOC3HDAC1HDAC6 | |
| SCHEMBL191430 | 0.78 | LMNA (0.46) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL190932 | 0.77 | AOC3 (0.40) | GCKAOC3MAOBHDAC1HDAC6 | |
| SCHEMBL27741187 | 0.76 | AOC3 (0.41) | GCKAOC3MAOBNPC1RAB9A | |
| SCHEMBL190970 | 0.76 | TRPV4 (0.40) | GCKAOC3NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL192244 | 0.76 | GCK (0.44) | GCKAOC3MAOBNPC1RAB9A | |
| SCHEMBL191341 | 0.76 | MEN1 (0.43) | GCKNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL190604 | 0.76 | GAA (0.43) | GCKAOC3MAOBNPC1RAB9A | |
| SCHEMBL190931 | 0.75 | AOC3 (0.42) | GCKAOC3MAOBHDAC1HDAC6 | |
| Hydrochloric Acid SCHEMBL191165 | 0.75 | GCK (0.43) | GCKAOC3MAOBNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1986645-B1 | GLUCOKINASE ACTIVATORS | ARRAY BIOPHARMA INC (US) | 2012-01-04 | — | — | EP | disclosed |