Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 17/20 | 0.56 |
| ▸ | OPRL1 | P41146 | 17/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19093376 | 0.76 | OPRL1 (0.66) | OPRM1OPRL1OPRK1 | |
| SCHEMBL17438942 | 0.76 | OPRM1 (0.66) | OPRM1OPRL1OPRK1 | |
| SCHEMBL3413521 | 0.75 | OPRL1 (1.00) | OPRM1OPRL1OPRK1 | |
| SCHEMBL12520508 | 0.74 | OPRL1 (0.68) | OPRM1OPRL1OPRK1 | |
| SCHEMBL3407434 | 0.74 | OPRL1 (0.68) | OPRM1OPRL1OPRK1 | |
| SCHEMBL19104856 | 0.74 | OPRM1 (0.57) | OPRM1OPRL1OPRK1 | |
| SCHEMBL3413008 | 0.74 | OPRL1 (0.61) | OPRM1OPRL1OPRK1 | |
| SCHEMBL19096726 | 0.73 | OPRM1 (0.66) | OPRM1OPRL1OPRK1 | |
| SCHEMBL19096721 | 0.73 | OPRM1 (0.66) | OPRM1OPRL1OPRK1 | |
| SCHEMBL696037 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230183222-A1 | 8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | GRUENENTHAL GMBH (DE) | 2023-06-15 | — | — | US | disclosed |
| CN-108602778-B | 8-amino-2-oxo-1, 3-diaza-spiro- [4.5] -decane derivatives | 格吕伦塔尔有限公司 | 2021-12-10 | — | — | CN | disclosed |
| US-20210179595-A1 | 8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | Grünenthal GmbH (DE) | 2021-06-17 | — | — | US | disclosed |
| US-20200399255-A1 | 8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | Grünenthal GmbH (DE) | 2020-12-24 | — | — | US | disclosed |
| US-10793556-B2 | 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives | GRUENENTHAL GMBH (DE) | 2020-10-06 | — | — | US | disclosed |
| EP-3402782-B1 | 8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2020-07-29 | — | — | EP | disclosed |
| US-20190100515-A1 | 8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2019-04-04 | — | — | US | disclosed |
| EP-3402782-A1 | 8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES | Grünenthal GmbH (DE) | 2018-11-21 | — | — | EP | disclosed |
| CN-108602778-A | 8-amino-2-oxo-1, 3-diaza-spiro- [4.5] -decane derivatives | 格吕伦塔尔有限公司 | 2018-09-28 | — | — | CN | disclosed |
| US-20180273516-A1 | 8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES | Grünenthal GmbH (DE) | 2018-09-27 | — | — | US | disclosed |
| WO-2017121650-A1 | 8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES | Grünenthal GmbH (DE) | 2017-07-20 | — | — | WO | disclosed |
| US-20170197949-A1 | 8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | GRUENENTHAL GMBH (DE) | 2017-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210179595-A1 | 8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | OPRK1, OPRD1, OPRL1 | OPRM1 7/4885OPRL1 3/4885OPRK1 1/4885 |
| US-20190100515-A1 | 8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES | OPRK1, OPRD1, OPRL1 | OPRM1 7/4885OPRL1 3/4885OPRK1 1/4885 |
| US-10793556-B2 | 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives | OPRK1, OPRD1, OPRL1 | OPRM1 7/4885OPRL1 3/4885OPRK1 1/4885 |
| US-20170197949-A1 | 8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | OPRK1, OPRD1, OPRL1 | OPRM1 7/4885OPRL1 3/4885OPRK1 1/4885 |
| US-20200399255-A1 | 8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | OPRK1, OPRD1, OPRL1 | OPRM1 8/4885OPRL1 3/4885OPRK1 1/4885 |
| US-20230183222-A1 | 8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | OPRK1, OPRD1, OPRL1 | OPRM1 7/4885OPRL1 3/4885OPRK1 1/4885 |
| US-20180273516-A1 | 8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES | OPRK1, OPRD1, OPRL1 | OPRM1 8/4885OPRL1 3/4885OPRK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.