Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 2/20 | 0.42 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.42 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.42 |
| ▸ | SAT1 | P21673 | 1/20 | 0.40 |
| ▸ | NCF1 | P14598 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.31 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.31 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.31 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19098392 | 0.89 | NCF1 (0.39) | GNAI3GNAO1GNAI1SAT1NCF1 | |
| SCHEMBL19780085 | 0.86 | SAT1 (0.39) | GNAI3GNAO1GNAI1SAT1 | |
| SCHEMBL19098397 | 0.84 | GNAI3 (0.39) | GNAI3GNAO1GNAI1SAT1NCF1 | |
| SCHEMBL10864747 | 0.83 | GNAI3 (0.50) | GNAI3GNAO1GNAI1SAT1NCF1 | |
| SCHEMBL19122646 | 0.81 | GNAI3 (0.46) | GNAI3GNAO1GNAI1SAT1CHRM3 | |
| SCHEMBL19098398 | 0.80 | SAT1 (0.36) | GNAI3GNAO1GNAI1SAT1 | |
| SCHEMBL19098394 | 0.79 | NCF1 (0.38) | GNAI3GNAO1GNAI1SAT1NCF1 | |
| SCHEMBL19098396 | 0.76 | CYP2C9 (0.35) | GNAI3GNAO1GNAI1SAT1NCF1 | |
| SCHEMBL12674143 | 0.76 | NCF1 (0.41) | GNAI3GNAO1GNAI1SAT1NCF1 | |
| SCHEMBL12778310 | 0.76 | NCF1 (0.41) | GNAI3GNAO1GNAI1SAT1NCF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017120164-A1 | FUSED QUADRACYCLIC COMPOUNDS, COMPOSITIONS AND USES THEREOF | Tabomedex Biosciences, LLC (US) | 2017-07-13 | — | — | WO | disclosed |
| US-20170190713-A1 | FUSED QUADRACYCLIC COMPOUNDS, COMPOSITIONS AND USES THEREOF | WUXI APPTEC (HONG KONG) CO., LIMITED (HK) | 2017-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170190713-A1 | FUSED QUADRACYCLIC COMPOUNDS, COMPOSITIONS AND USES THEREOF | MKNK2, CYP2J2, PTGS2 | GNAI3 261/4885GNAO1 1468/4885GNAI1 281/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.