Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | HSD17B1 | P14061 | 4/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | TDP2 | O95551 | 4/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.33 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.32 |
| ▸ | ESR1 | P03372 | 2/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19100863 | 0.73 | HSD17B1 (0.66) | CA1CA2DAPK3NTRK1PIM1 | |
| SCHEMBL6188618 | 0.72 | TDP2 (0.55) | PGRTDP2PARP10PARP11DGAT1 | |
| SCHEMBL19100613 | 0.71 | CA1 (0.40) | CA1CA2DAPK3NTRK1PIM1 | |
| SCHEMBL6979410 | 0.70 | PARP10 (0.55) | PGRTDP2PARP10PARP11DGAT1 | |
| SCHEMBL28355091 | 0.70 | TDP2 (0.47) | CA1CA2TDP2PARP10PARP11 | |
| SCHEMBL28744563 | 0.69 | CA1 (0.48) | CA1CA2DAPK3NTRK1PIM1 | |
| SCHEMBL19116652 | 0.69 | CA1 (0.40) | CA1CA2DAPK3NTRK1PIM1 | |
| SCHEMBL19116668 | 0.69 | CA1 (0.40) | CA1CA2HSD17B1ALDH1A1 | |
| SCHEMBL14060473 | 0.68 | CA1 (0.43) | CA1CA2TDP2PARP10 | |
| SCHEMBL19116369 | 0.67 | PBRM1 (0.54) | CA1CA2HSD17B1TDP2FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200331828-A1 | NOVEL COMPOUNDS WHICH ACTIVATE ESTROGEN RECEPTORS AND COMPOSITIONS AND METHODS OF USING THE SAME | UNIV ILLINOIS (US) | 2020-10-22 | — | — | US | disclosed |
| US-10703698-B2 | Compounds which activate estrogen receptors and compositions and methods of using the same | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2020-07-07 | — | — | US | disclosed |
| US-20190002380-A1 | NOVEL COMPOUNDS WHICH ACTIVATE ESTROGEN RECEPTORS AND COMPOSITIONS AND METHODS OF USING THE SAME | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2019-01-03 | — | — | US | disclosed |
| EP-3400071-A1 | NOVEL COMPOUNDS WHICH ACTIVATE ESTROGEN RECEPTORS AND COMPOSITIONS AND METHODS OF USING THE SAME | The Board of Trustees of the University of Illinois (US) | 2018-11-14 | — | — | EP | disclosed |
| WO-2017120507-A1 | NOVEL COMPOUNDS WHICH ACTIVATE ESTROGEN RECEPTORS AND COMPOSITIONS AND METHODS OF USING THE SAME | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2017-07-13 | — | — | WO | disclosed |
| WO-2017120507-A1 | NOVEL COMPOUNDS WHICH ACTIVATE ESTROGEN RECEPTORS AND COMPOSITIONS AND METHODS OF USING THE SAME | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2017-07-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10703698-B2 | Compounds which activate estrogen receptors and compositions and methods of using the same | GPER1, ESRRG, ESR2 | CA1 618/4885CA2 2016/4885DAPK3 2207/4885 |
| US-20190002380-A1 | NOVEL COMPOUNDS WHICH ACTIVATE ESTROGEN RECEPTORS AND COMPOSITIONS AND METHODS OF USING THE SAME | GPER1, ESRRG, ESR2 | CA1 810/4885CA2 2607/4885DAPK3 2173/4885 |
| US-20200331828-A1 | NOVEL COMPOUNDS WHICH ACTIVATE ESTROGEN RECEPTORS AND COMPOSITIONS AND METHODS OF USING THE SAME | GPER1, ESRRG, ESR2 | CA1 810/4885CA2 2607/4885DAPK3 2173/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.