Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | DRD4 | P21917 | 3/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 4/20 | 0.39 |
| ▸ | CNR2 | P34972 | 6/20 | 0.34 |
| ▸ | CNR1 | P21554 | 4/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.33 |
| ▸ | PTGES | O14684 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17297856 | 0.90 | DRD4 (0.36) | DRD2DRD4PDE3BPDE3ACYP2D6 | |
| SCHEMBL17297943 | 0.83 | MTNR1A (0.36) | PDE3BPDE3ACYP2D6LDHABRD4 | |
| SCHEMBL19477775 | 0.81 | LDHA (0.34) | PDE3BPDE3ACYP2D6LDHATP53 | |
| SCHEMBL17297804 | 0.76 | TP53 (0.35) | DRD2DRD4CNR2CNR1CYP2D6 | |
| SCHEMBL17297857 | 0.74 | LDHA (0.34) | DRD2DRD4CYP2D6LDHABRD4 | |
| SCHEMBL20749729 | 0.72 | EZH2 (0.43) | PDE3BPDE3A | |
| SCHEMBL17297854 | 0.71 | DRD4 (0.36) | DRD2DRD4 | |
| SCHEMBL17297973 | 0.69 | LDHA (0.37) | CYP2D6LDHATP53 | |
| SCHEMBL19102341 | 0.69 | RIPK1 (0.43) | DRD2DRD4RIPK1CNR2CNR1 | |
| SCHEMBL17297944 | 0.68 | LDHA (0.35) | PDE3BPDE3ACYP2D6LDHABRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9701666-B2 | 1,4-pyridone bicyclic heteroaryl compounds | Epizyme, Inc. (US) | 2017-07-11 | — | — | US | disclosed |