Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | MPO | P05164 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18235895 | 0.89 | MAOA (0.36) | SMN1; SMN2MEN1KMT2ACHRM2MPO | |
| SCHEMBL18235892 | 0.82 | BACE1 (0.42) | BACE1BACE2SLC6A4 | |
| SCHEMBL18232514 | 0.78 | DPP4 (0.35) | SMN1; SMN2BACE1BACE2SLC6A4 | |
| SCHEMBL13975424 | 0.76 | ACHE (0.52) | SMN1; SMN2MEN1KMT2ACHRM2MPO | |
| SCHEMBL3139434 | 0.76 | USP28 (0.39) | SMN1; SMN2MEN1KMT2AMPOBACE1 | |
| SCHEMBL21799866 | 0.75 | CHRM2 (0.49) | CHRM2TSHRCYP2D6CYP3A4 | |
| SCHEMBL24067917 | 0.75 | MEN1 (0.43) | SMN1; SMN2MEN1KMT2AHRH4HRH3 | |
| SCHEMBL13104119 | 0.75 | SCN8A (0.41) | SMN1; SMN2MEN1KMT2AHRH4HRH3 | |
| SCHEMBL18232492 | 0.74 | DPP4 (0.37) | BACE1BACE2 | |
| SCHEMBL10045212 | 0.74 | USP28 (0.40) | CHRM2MPOTSHRBACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9701628-B2 | 12-epi pleuromutilins | NABRIVA THERAPEUTICS AG (AT) | 2017-07-11 | — | — | US | disclosed |