Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 6/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.39 |
| ▸ | ESRRA | P11474 | 1/20 | 0.38 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MDM4 | O15151 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TYR | P14679 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15686706 | 0.80 | RXRA (0.43) | RXRAGRIN1GRIN2BNOTUMESRRA | |
| SCHEMBL19106908 | 0.78 | NOTUM (0.50) | NOTUMESRRAALDH1A1MAPTTDP1 | |
| SCHEMBL7994256 | 0.73 | NOTUM (0.42) | RXRAGRIN1GRIN2BNOTUMESRRA | |
| SCHEMBL8470236 | 0.73 | PDPK1 (0.35) | — | |
| SCHEMBL9272142 | 0.73 | MEN1 (0.42) | ALDH1A1CA2CYP3A4CA5ASMN1; SMN2 | |
| SCHEMBL8230259 | 0.73 | NOTUM (0.51) | NOTUMKDM4EALDH1A1TP53CYP3A4 | |
| SCHEMBL7994431 | 0.71 | NOTUM (0.65) | RXRAGRIN1GRIN2BNOTUMALDH1A1 | |
| SCHEMBL15362397 | 0.71 | NOTUM (0.65) | RXRAGRIN1GRIN2BNOTUMESRRA | |
| SCHEMBL2211763 | 0.71 | KDM4E (0.46) | NOTUMHPGDKDM4EALDH1A1MAPT | |
| SCHEMBL19836609 | 0.70 | RXRA (0.42) | RXRAGRIN1GRIN2BNOTUMESRRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9926317-B2 | Inhibitors of the renal outer medullary potassium channel | MERCK SHARP DOHME CORP. (US) | 2018-03-27 | — | — | US | disclosed |
| US-20170197964-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME LLC | 2017-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170197964-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | KCNJ11, KCNJ1, KCNJ2 | RXRA 4120/4885GRIN1 547/4885GRIN2B 1121/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.