Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.56 |
| ▸ | CA2 | P00918 | 2/20 | 0.56 |
| ▸ | BCHE | P06276 | 1/20 | 0.56 |
| ▸ | ACHE | P22303 | 1/20 | 0.56 |
| ▸ | CES2 | O00748 | 1/20 | 0.51 |
| ▸ | CES1 | P23141 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19097634 | 0.89 | CA1 (0.46) | CA1CA2BCHEACHECES2 | |
| SCHEMBL15086926 | 0.87 | CA1 (0.61) | CA1CA2BCHEACHECES2 | |
| SCHEMBL19118022 | 0.84 | ALDH1A1 (0.57) | CA1CA2BCHEACHECES2 | |
| SCHEMBL2596732 | 0.83 | CA1 (0.74) | CA1CA2BCHEACHECES2 | |
| SCHEMBL6388669 | 0.82 | CES2 (0.69) | CA1CA2BCHEACHECES2 | |
| SCHEMBL1363813 | 0.82 | CA1 (0.67) | CA1CA2BCHEACHECES2 | |
| SCHEMBL16317650 | 0.81 | CA1 (0.51) | CA1CA2BCHEACHECES2 | |
| SCHEMBL19097630 | 0.79 | ALDH1A1 (0.48) | CA1CA2BCHEACHECES2 | |
| SCHEMBL25931268 | 0.78 | ALDH1A1 (0.65) | CA1CA2BCHEACHECES2 | |
| SCHEMBL18214656 | 0.77 | CA1 (0.54) | CA1CA2BCHEACHECES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130343994-A1 | Cholinesterase Inhibitors | THE UNIVERSITY OF MONTANA (US) | 2013-12-26 | — | — | US | claimed |
| US-20170197996-A1 | Cholinesterase Inhibitors | THE UNIVERSITY OF MONTANA (US) | 2017-07-13 | — | — | US | disclosed |
| US-20170197996-A1 | Cholinesterase Inhibitors | THE UNIVERSITY OF MONTANA (US) | 2017-07-13 | — | — | US | disclosed |
| US-20170197996-A1 | Cholinesterase Inhibitors | THE UNIVERSITY OF MONTANA (US) | 2017-07-13 | — | — | US | disclosed |
| US-20130343994-A1 | Cholinesterase Inhibitors | THE UNIVERSITY OF MONTANA (US) | 2013-12-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170197996-A1 | Cholinesterase Inhibitors | BCHE, ACHE, BACE1 | CA1 418/4885CA2 2259/4885BCHE 1/4885 |
| US-20130343994-A1 | Cholinesterase Inhibitors | BCHE, ACHE, BACE1 | CA1 418/4885CA2 2259/4885BCHE 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.