Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | THRA | P10827 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | RXRB | P28702 | 1/20 | 0.43 |
| ▸ | RXRG | P48443 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.43 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8312391 | 0.84 | NISCH (0.51) | NISCHALDH1A1MEN1KMT2ASIGMAR1 | |
| SCHEMBL7905159 | 0.84 | BCL2L1 (0.54) | ALDH1A1MEN1KMT2ASIGMAR1LMNA | |
| SCHEMBL3366873 | 0.80 | ALDH1A1 (0.54) | NISCHALDH1A1MEN1KMT2ASIGMAR1 | |
| SCHEMBL20866604 | 0.78 | ALDH1A1 (0.53) | NISCHALDH1A1MEN1KMT2ASIGMAR1 | |
| SCHEMBL11456138 | 0.77 | NISCH (0.49) | NISCHALDH1A1MEN1KMT2ASIGMAR1 | |
| SCHEMBL4042587 | 0.76 | SIGMAR1 (0.53) | NISCHALDH1A1MEN1KMT2ASIGMAR1 | |
| SCHEMBL25796675 | 0.76 | SIGMAR1 (0.49) | NISCHALDH1A1MEN1KMT2ASIGMAR1 | |
| SCHEMBL12403846 | 0.76 | NISCH (0.48) | NISCHALDH1A1MEN1KMT2ASIGMAR1 | |
| SCHEMBL12471303 | 0.76 | HTT (0.54) | NISCHALDH1A1MEN1KMT2ASIGMAR1 | |
| SCHEMBL12101466 | 0.75 | MEN1 (0.56) | NISCHALDH1A1MEN1KMT2ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2380879-B1 | Tetrahydroindolone and tetrahydroindazolone derivatives | ESANEX INC (US) | 2017-07-12 | — | — | EP | disclosed |