Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1I | Q9P0X4 | 7/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13569794 | 0.85 | CACNA1I (0.50) | CACNA1IKCNH2CACNA1HCYP2D6HDAC4 | |
| SCHEMBL19113313 | 0.83 | CARM1 (0.56) | CACNA1IKCNH2CHRM2CHRM1CACNA1H | |
| SCHEMBL20056282 | 0.80 | CHRM2 (0.55) | CACNA1IKCNH2CHRM2CHRM1CACNA1H | |
| SCHEMBL19113186 | 0.79 | CHRM2 (0.55) | CACNA1IKCNH2CHRM2CHRM1HDAC4 | |
| SCHEMBL4284039 | 0.79 | CHRM2 (0.51) | CACNA1IKCNH2CHRM2CHRM1CACNA1H | |
| SCHEMBL4277358 | 0.78 | CHRM2 (0.52) | CACNA1IKCNH2CHRM2CHRM1CACNA1H | |
| SCHEMBL19112914 | 0.78 | EPHX2 (0.50) | CACNA1IKCNH2CHRM2CHRM1CACNA1H | |
| SCHEMBL13569924 | 0.78 | CACNA1I (0.54) | CACNA1IKCNH2CACNA1HCYP2D6 | |
| SCHEMBL19112915 | 0.77 | EPHX2 (0.52) | CACNA1IKCNH2CHRM2CHRM1CHRM4 | |
| SCHEMBL13569699 | 0.77 | KCNH2 (0.63) | CACNA1IKCNH2CACNA1HCYP2D6KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189839-B1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | PRAXIS PREC MEDICINES INC (US) | 2020-05-20 | — | — | EP | disclosed |
| EP-3189839-A1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | Taro Pharmaceuticals Inc. (CA) | 2017-07-12 | — | — | EP | disclosed |