Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 18/20 | 0.56 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10282959 | 0.89 | REN (0.59) | RENCDK9 | |
| SCHEMBL10283299 | 0.85 | REN (0.57) | RENCDK9 | |
| SCHEMBL1911386 | 0.85 | REN (0.56) | RENCDK9 | |
| SCHEMBL90547 | 0.81 | REN (0.60) | REN | |
| SCHEMBL1911384 | 0.79 | MEN1 (0.46) | REN | |
| SCHEMBL89110 | 0.78 | REN (0.53) | REN | |
| SCHEMBL8235692 | 0.78 | REN (0.46) | REN | |
| SCHEMBL89132 | 0.78 | REN (0.43) | REN | |
| SCHEMBL1911408 | 0.76 | REN (0.55) | REN | |
| SCHEMBL89889 | 0.74 | PDE4B (0.38) | RENNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2420491-A1 | 3 , 5-substitued piperidine compounds as renin inhibitors | Novartis AG (CH) | 2012-02-22 | — | — | EP | disclosed |
| WO-2007077005-A1 | 3 , 5-SUBSTITΓUED PIPERIDINE COMPOUNDS AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2007-07-12 | — | — | WO | disclosed |