Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 10/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | PI4KA | P42356 | 1/20 | 0.39 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.39 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.39 |
| ▸ | F7 | P08709 | 1/20 | 0.38 |
| ▸ | F3 | P13726 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10307718 | 0.82 | PDE2A (0.43) | PDE2AKMT2AMEN1PI4KAPI4K2B | |
| SCHEMBL31391465 | 0.80 | PDE2A (0.42) | PDE2AKMT2AMEN1PI4KAPI4K2B | |
| SCHEMBL25746365 | 0.80 | PDE2A (0.42) | PDE2AKMT2AMEN1PI4KAPI4K2B | |
| SCHEMBL4409891 | 0.78 | PI4KA (0.55) | PDE2AKMT2AMEN1PI4KAPI4K2B | |
| SCHEMBL18343699 | 0.78 | PDE2A (0.49) | PDE2AKMT2AMEN1PI4KAPI4K2B | |
| SCHEMBL6342897 | 0.78 | PDE2A (0.41) | PDE2AKMT2AMEN1PI4KAPI4K2B | |
| SCHEMBL26817446 | 0.76 | PDE2A (0.42) | PDE2AKMT2AMEN1PI4KAPI4K2B | |
| SCHEMBL21818491 | 0.73 | ATAD2 (0.44) | PDE2AKMT2AMEN1PI4KAPI4K2B | |
| SCHEMBL31133306 | 0.73 | ATAD2 (0.44) | PDE2AKMT2AMEN1PI4KAPI4K2B | |
| SCHEMBL31249005 | 0.70 | HRH4 (0.51) | KMT2AMEN1ALDH1A1HRH1HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017120429-A1 | SELECTIVE INHIBITORS OF CLINICALLY IMPORTANT MUTANTS OF THE EGFR TYROSINE KINASE | CS Pharmasciences, Inc. (US) | 2017-07-13 | — | — | WO | disclosed |