Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR4 | P51679 | 2/20 | 0.50 |
| ▸ | CFTR | P13569 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 3/20 | 0.41 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL263507 | 0.99 | CCR4 (0.51) | CCR4CFTRGAAKDM4EMAPT | |
| SCHEMBL5439494 | 0.89 | CCR4 (0.51) | CCR4CFTRGAAKDM4EMAPT | |
| SCHEMBL19119063 | 0.86 | CCR4 (0.46) | CCR4CFTRGAAKDM4EMAPT | |
| SCHEMBL29274266 | 0.81 | ALOX5 (0.59) | CCR4CFTRGAAKDM4EMAPT | |
| SCHEMBL1821848 | 0.79 | ALOX5 (0.60) | CCR4CFTRGAAKDM4EMAPT | |
| SCHEMBL2185593 | 0.79 | FFAR2 (0.50) | CCR4CFTRGAAMAPTNPC1 | |
| SCHEMBL27818106 | 0.79 | FFAR2 (0.50) | CCR4CFTRGAAMAPTNPC1 | |
| Propionic Acid SCHEMBL27837747 | 0.79 | GAA (0.47) | CCR4CFTRGAAKDM4EMAPT | |
| SCHEMBL14625491 | 0.79 | CCR4 (0.51) | CCR4CFTRGAAKDM4EMAPT | |
| SCHEMBL5437969 | 0.78 | KDM1A (0.59) | CCR4CFTRGAAKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3192504-A1 | IL-8 INHIBITORS FOR USE IN THE TREATMENT OF CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY | Dompé farmaceutici S.p.A. (IT) | 2017-07-19 | — | — | EP | claimed |
| EP-3402474-B1 | IL-8 INHIBITORS FOR USE IN THE TREATMENT OF CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY | DOMPE FARM SPA (IT) | 2021-07-21 | — | — | EP | disclosed |
| US-20190015391-A1 | IL-8 INHIBITORS FOR USE IN THE TREATMENT OF CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2019-01-17 | — | — | US | disclosed |
| EP-3402474-A1 | IL-8 INHIBITORS FOR USE IN THE TREATMENT OF CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY | Dompé farmaceutici S.p.A. (IT) | 2018-11-21 | — | — | EP | disclosed |
| WO-2017121838-A1 | IL-8 INHIBITORS FOR USE IN THE TREATMENT OF CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY | DOMPE' FARMACEUTICI S.P.A. (IT) | 2017-07-20 | — | — | WO | disclosed |
| EP-3192504-A1 | IL-8 INHIBITORS FOR USE IN THE TREATMENT OF CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY | Dompé farmaceutici S.p.A. (IT) | 2017-07-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190015391-A1 | IL-8 INHIBITORS FOR USE IN THE TREATMENT OF CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY | CXCL8, CCR8, CXCR1 | CCR4 31/4885CFTR 2371/4885GAA 4859/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.