Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 10/20 | 0.42 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19086059 | 0.80 | NTRK1 (0.37) | NTRK1MEN1KMT2AMAPK14 | |
| SCHEMBL22381401 | 0.74 | ALDH1A1 (0.43) | NTRK1MEN1TSHRMAPK1KMT2A | |
| SCHEMBL2571668 | 0.74 | NTRK1 (0.38) | NTRK1MEN1TSHRMAPK1KMT2A | |
| SCHEMBL23937854 | 0.72 | NTRK1 (0.41) | NTRK1MEN1TSHRMAPK1KMT2A | |
| SCHEMBL26328680 | 0.71 | NTRK1 (0.38) | NTRK1MEN1TSHRMAPK1KMT2A | |
| SCHEMBL20952658 | 0.70 | KIT (0.39) | NTRK1MEN1TSHRMAPK1KMT2A | |
| SCHEMBL16171674 | 0.70 | NTRK1 (0.38) | NTRK1MEN1TSHRMAPK1KMT2A | |
| SCHEMBL12985708 | 0.70 | SMYD3 (0.42) | NTRK1MEN1TSHRMAPK1KMT2A | |
| SCHEMBL20546482 | 0.68 | MAPK1 (0.57) | NTRK1MEN1TSHRMAPK1KMT2A | |
| SCHEMBL20547099 | 0.68 | MEN1 (0.56) | NTRK1MEN1TSHRMAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170197947-A1 | 3-((Hetero-)Aryl)-Alkyl-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | GRUENENTHAL GMBH (DE) | 2017-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170197947-A1 | 3-((Hetero-)Aryl)-Alkyl-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | OPRK1, OPRD1, ARRB1 | NTRK1 586/4885GPR139 404/4885MEN1 3999/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.