Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 4/20 | 0.46 |
| ▸ | DRD4 | P21917 | 3/20 | 0.46 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.45 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.45 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | UCHL1 | P09936 | 3/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19122920 | 0.90 | KMT2A (0.49) | HTTKMT2AALDH1A1SMN1; SMN2DRD2 | |
| SCHEMBL19122868 | 0.85 | UTS2R (0.48) | HTTGLAKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL19121980 | 0.84 | KMT2A (0.44) | HTTKMT2AALDH1A1SMN1; SMN2ROCK2 | |
| SCHEMBL19122989 | 0.84 | DRD4 (0.55) | DRD2DRD4 | |
| SCHEMBL17269855 | 0.84 | THRB (0.56) | HTTKMT2ADRD2DRD4THRB | |
| SCHEMBL19122940 | 0.80 | MEN1 (0.48) | HTTKMT2AALDH1A1DRD2DRD4 | |
| SCHEMBL19122562 | 0.80 | THRB (0.56) | HTTKMT2AALDH1A1SMN1; SMN2DRD2 | |
| SCHEMBL2961446 | 0.79 | HTR1A (0.61) | HTTKMT2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL2961452 | 0.79 | HTR1A (0.61) | HTTKMT2AALDH1A1SMN1; SMN2MEN1 | |
| Gyramide C SCHEMBL19107768 | 0.78 | USP30 (0.57) | KMT2ADRD2DRD4MEN1USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10253039-B2 | Inhibitors of bacterial DNA gyrase with efficacy against gram-negative bacteria | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2019-04-09 | — | — | US | disclosed |
| US-20170197981-A1 | INHIBITORS OF BACTERIAL DNA GYRASE WITH EFFICACY AGAINST GRAM-NEGATIVE BACTERIA | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170197981-A1 | INHIBITORS OF BACTERIAL DNA GYRASE WITH EFFICACY AGAINST GRAM-NEGATIVE BACTERIA | TOP1, TOP2A, TOP2B | HTT 3909/4885GLA 209/4885KMT2A 1434/4885 |
| US-10253039-B2 | Inhibitors of bacterial DNA gyrase with efficacy against gram-negative bacteria | TOP1, TOP2A, TOP2B | HTT 3909/4885GLA 209/4885KMT2A 1434/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.