Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | FPR3 | P25089 | 1/20 | 0.43 |
| ▸ | FPR2 | P25090 | 1/20 | 0.43 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17572258 | 0.87 | FPR3 (0.43) | FPR3FPR2AAK1PDK2TRPV4 | |
| SCHEMBL20884885 | 0.87 | AAK1 (0.44) | MAPTFPR3FPR2AAK1PDK2 | |
| SCHEMBL12311224 | 0.87 | GBA1 (0.44) | MAPTFPR3FPR2AAK1PDK2 | |
| SCHEMBL23099550 | 0.85 | AAK1 (0.43) | FPR3FPR2AAK1PDK2TRPV4 | |
| SCHEMBL23099545 | 0.84 | FPR3 (0.41) | MAPTFPR3FPR2AAK1PDK2 | |
| SCHEMBL20874117 | 0.83 | MAPT (0.52) | MAPTPOLBKMT2AMEN1HTT | |
| SCHEMBL14679115 | 0.81 | NPC1 (0.51) | POLBLMNAKMT2AMEN1HTT | |
| SCHEMBL1979475 | 0.80 | MCHR1 (0.42) | FPR3FPR2CA14LMNACYP1A2 | |
| SCHEMBL30264506 | 0.78 | LTB4R (0.46) | MAPTPDK2KCNH2HRH3RAB9A | |
| SCHEMBL19112868 | 0.77 | GAA (0.52) | MAPTPOLBLMNAKMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3190111-B1 | PYRAZOLO[3,4-C]PYRIDINE DERIVATIVES | CSPC ZHONGQI PHARMACEUTICAL TECH SHIJIAZHUANG CO LTD (CN) | 2020-05-06 | — | — | EP | disclosed |
| EP-3190111-A1 | PYRAZOLO[3,4-C]PYRIDINE DERIVATIVES | CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. (CN) | 2017-07-12 | — | — | EP | disclosed |