Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.44 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | CDC25B | P30305 | 1/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.39 |
| ▸ | GCGR | P47871 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 2/20 | 0.38 |
| ▸ | CCNC | P24863 | 2/20 | 0.38 |
| ▸ | CDK8 | P49336 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11379135 | 0.82 | SLC22A12 (0.46) | SLC22A12RPS6KA3NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2556296 | 0.82 | SLC22A12 (0.44) | SLC22A12RPS6KA3SMN1; SMN2ALDH1A1ERN1 | |
| SCHEMBL11383161 | 0.81 | CCNC (0.46) | SLC22A12RPS6KA3SMN1; SMN2ALDH1A1ERN1 | |
| SCHEMBL15652488 | 0.81 | SLC22A12 (0.48) | SLC22A12RPS6KA3ALDH1A1ERN1CCNC | |
| SCHEMBL29681568 | 0.81 | CCNT1 (0.42) | ERN1CCNCCDK8 | |
| SCHEMBL4294149 | 0.81 | TDP1 (0.48) | XDHCDC25BSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL6824324 | 0.79 | CACNA1B (0.40) | XDHRPS6KA3ALDH1A1ERN1CCNC | |
| SCHEMBL30479910 | 0.78 | SLC22A12 (0.49) | SLC22A12RPS6KA3NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2559873 | 0.77 | MKNK1 (0.51) | SLC22A12ERN1CCNCCDK8 | |
| SCHEMBL28279885 | 0.77 | RPS6KA3 (0.63) | SLC22A12CDC25BRPS6KA3GCGRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10654878-B2 | Compounds of phosphinanes and azaphosphinanes, a process for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2020-05-19 | — | — | US | disclosed |
| US-20190031693-A1 | COMPOUNDS OF PHOSPHINANES AND AZAPHOSPHINANES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES SERVIER (FR) | 2019-01-31 | — | — | US | disclosed |
| US-10138260-B2 | Compounds of phosphinanes and azaphosphinanes, a process for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2018-11-27 | — | — | US | disclosed |
| EP-3271368-B1 | NOVEL PHOSPHINANE AND AZAPHOSPHINANE DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SERVIER LAB (FR) | 2018-10-31 | — | — | EP | disclosed |
| CN-108495857-A | New phospha cyclohexane class compound and azepine phospha cyclohexane class compound, their preparation method and the Pharmaceutical composition comprising them | 法国施维雅药厂 | 2018-09-04 | — | — | CN | disclosed |
| EP-3271368-A1 | NOVEL PHOSPHINANE AND AZAPHOSPHINANE DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | Les Laboratoires Servier (FR) | 2018-01-24 | — | — | EP | disclosed |
| US-20180016288-A1 | COMPOUNDS OF PHOSPHINANES AND AZAPHOSPHINANES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES SERVIER (FR) | 2018-01-18 | — | — | US | disclosed |
| WO-2017121969-A1 | NOVEL PHOSPHINANE AND AZAPHOSPHINANE DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2017-07-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10654878-B2 | Compounds of phosphinanes and azaphosphinanes, a process for their preparation and pharmaceutical compositions containing them | TK1, AK1, PHKA1 | SLC22A12 3542/4885XDH 1074/4885CDC25B 725/4885 |
| US-10138260-B2 | Compounds of phosphinanes and azaphosphinanes, a process for their preparation and pharmaceutical compositions containing them | TK1, AK1, PHKA1 | SLC22A12 3542/4885XDH 1074/4885CDC25B 725/4885 |
| US-20180016288-A1 | COMPOUNDS OF PHOSPHINANES AND AZAPHOSPHINANES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | TK1, AK1, PHKA1 | SLC22A12 3542/4885XDH 1074/4885CDC25B 725/4885 |
| US-20190031693-A1 | COMPOUNDS OF PHOSPHINANES AND AZAPHOSPHINANES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | AK1, TK1, PHKA1 | SLC22A12 3735/4885XDH 949/4885CDC25B 699/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.