Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 6/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | PSMB1 | P20618 | 3/20 | 0.51 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.51 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19126575 | 0.84 | GPR119 (0.48) | HTT | |
| SCHEMBL19126531 | 0.82 | TERT (0.44) | TDP1 | |
| SCHEMBL19126487 | 0.79 | EPHX2 (0.49) | — | |
| SCHEMBL19126553 | 0.78 | KDM4E (0.56) | KDM4EALDH1A1NOTUM | |
| SCHEMBL7240783 | 0.77 | PSMB1 (0.65) | LTA4HKDM4EPSMB1PSMB5PSMB2 | |
| SCHEMBL2741674 | 0.76 | PSMB1 (0.68) | LTA4HKDM4EPSMB1PSMB5PSMB2 | |
| SCHEMBL2741675 | 0.76 | PSMB1 (0.68) | LTA4HKDM4EPSMB1PSMB5PSMB2 | |
| Hydrochloric Acid SCHEMBL228735 | 0.75 | PSMB1 (0.66) | LTA4HKDM4EPSMB1PSMB5PSMB2 | |
| Hydrochloric Acid SCHEMBL228395 | 0.75 | PSMB1 (0.66) | LTA4HKDM4EPSMB1PSMB5PSMB2 | |
| SCHEMBL19145647 | 0.74 | HPGD (0.54) | KDM4EALDH1A1NOTUMPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11939314-B2 | Quinolin-2-one derivatives | MERCK PATENT GMBH (DE) | 2024-03-26 | — | — | US | disclosed |
| US-20230028687-A1 | QUINOLIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2023-01-26 | — | — | US | disclosed |
| US-20230028687-A1 | QUINOLIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2023-01-26 | — | — | US | disclosed |
| US-11186562-B2 | Quinolin-2-one derivatives | MERCK PATENT GMBH (DE) | 2021-11-30 | — | — | US | disclosed |
| US-11186562-B2 | Quinolin-2-one derivatives | MERCK PATENT GMBH (DE) | 2021-11-30 | — | — | US | disclosed |
| US-11174241-B2 | Quinolin-2-one derivatives | MERCK PATENT GMBH (DE) | 2021-11-16 | — | — | US | disclosed |
| US-11174241-B2 | Quinolin-2-one derivatives | MERCK PATENT GMBH (DE) | 2021-11-16 | — | — | US | disclosed |
| CN-108473485-B | Quinolin-2-one derivatives | 默克专利股份公司 | 2021-11-02 | — | — | CN | disclosed |
| US-20200190055-A1 | QUINOLIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2020-06-18 | — | — | US | disclosed |
| US-20200190054-A1 | QUINOLIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2020-06-18 | — | — | US | disclosed |
| US-20200190055-A1 | QUINOLIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2020-06-18 | — | — | US | disclosed |
| US-20200190054-A1 | QUINOLIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2020-06-18 | — | — | US | disclosed |
| US-10669251-B2 | Quinolin-2-one derivatives | MERCK PATENT GMBH (DE) | 2020-06-02 | — | — | US | disclosed |
| US-10669251-B2 | Quinolin-2-one derivatives | MERCK PATENT GMBH (DE) | 2020-06-02 | — | — | US | disclosed |
| US-20190023685-A1 | QUINOLIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2019-01-24 | — | — | US | disclosed |
| US-20190023685-A1 | QUINOLIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2019-01-24 | — | — | US | disclosed |
| EP-3402792-A1 | QUINOLIN-2-ONE DERIVATIVES | Merck Patent GmbH (DE) | 2018-11-21 | — | — | EP | disclosed |
| WO-2017121444-A1 | QUINOLIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2017-07-20 | — | — | WO | disclosed |
| WO-2017121444-A1 | QUINOLIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2017-07-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11174241-B2 | Quinolin-2-one derivatives | KIT, CDK2, CDK1 | LTA4H 4202/4885KDM4E 460/4885PSMB1 3519/4885 |
| US-20190023685-A1 | QUINOLIN-2-ONE DERIVATIVES | KIT, CDK2, CDK1 | LTA4H 4202/4885KDM4E 460/4885PSMB1 3519/4885 |
| US-20200190054-A1 | QUINOLIN-2-ONE DERIVATIVES | KIT, CDK2, CDK1 | LTA4H 4202/4885KDM4E 460/4885PSMB1 3519/4885 |
| US-11939314-B2 | Quinolin-2-one derivatives | KIT, CDK2, CDK1 | LTA4H 4202/4885KDM4E 460/4885PSMB1 3519/4885 |
| US-20230028687-A1 | QUINOLIN-2-ONE DERIVATIVES | KIT, CDK2, CDK1 | LTA4H 4202/4885KDM4E 460/4885PSMB1 3519/4885 |
| US-20200190055-A1 | QUINOLIN-2-ONE DERIVATIVES | KIT, CDK2, CDK1 | LTA4H 4202/4885KDM4E 460/4885PSMB1 3519/4885 |
| US-10669251-B2 | Quinolin-2-one derivatives | KIT, CDK2, CDK1 | LTA4H 4202/4885KDM4E 460/4885PSMB1 3519/4885 |
| US-11186562-B2 | Quinolin-2-one derivatives | KIT, CDK2, CDK1 | LTA4H 4202/4885KDM4E 460/4885PSMB1 3519/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.